Western blot: Approx. 50kDa band observed in Mouse Ovary lysates and in preliminary testing of Human Uterus and Rat Ovary lysate (calculated MW of 38.9kDa according to Mouse NP_036150.1). This molecular weight is routinely observed by other sources. Primary incubation 1 hour at room temperature.
IHC-WhMt usage reported in scientific literature (PMID: 24753105). ICC/IF reported in scientific literature (PMID: 27698028). IHC-Fr reported in scientific literature (PMID: 23091613). ChIP reported in scientific literature (PMID: 30212841). IHC-P reported in scientific literature (PMID: 30304016).
Read 1 Review rated 5 using NB100-1277 in the following applications:
Use in Bovine, Human, Mouse reported in scientific literature (PMID: 33956944). Ferret reactivity reported in scientific literature (PMID: 25289806).
Packaging, Storage & Formulations
Store at -20C. Avoid freeze-thaw cycles.
Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
0.02% Sodium Azide
Immunogen affinity purified
Alternate Names for FOXL2 Antibody
forkhead box L2
forkhead box protein L2
forkhead transcription factor FOXL2
There are 2 forms of the blepharophimosis/ptosis/epicanthus inversus syndrome. In one form, called type I, eyelid abnormalities are associated with ovarian failure. In the second type, called type II, only the eyelid defects are found. Both types map to 3q23. Crisponi et al. (2001) refined the physical mapping of the BPES critical region and positionally cloned a novel, putative winged helix/forkhead transcription factor gene, FOXL2, in which they found mutations to produce truncated proteins in type I families and larger proteins in type II. Consistent with an involvement in those tissues, FOXL2 was selectively expressed in the mesenchyme of developing mouse eyelids and in adult ovarian follicles; in adult humans, it appeared predominantly in the ovary.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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