Fes Antibody (5A11G5)

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Western Blot: Fes Antibody (5A11G5) [NBP1-28881] - Western blot analysis using FES mouse mAb against truncated FES recombinant protein.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ELISA, ICC/IF
Clone
5A11G5
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

Fes Antibody (5A11G5) Summary

Immunogen
Purified recombinant fragment of FES expressed in E. Coli.
Specificity
Specific for FES.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
FES
Purity
Unpurified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • ELISA 1:100-1:2000
  • Immunocytochemistry/Immunofluorescence 1:200-1:1000

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
Ascites
Preservative
0.03% Sodium Azide
Purity
Unpurified

Alternate Names for Fes Antibody (5A11G5)

  • EC 2.7.10
  • EC 2.7.10.2
  • feline sarcoma oncogene
  • feline sarcoma virus
  • Fes
  • FPS
  • Proto-oncogene c-Fes
  • Proto-oncogene c-Fps
  • proto-oncogene tyrosine-protein kinase Fes/Fps
  • tyrosine-protein kinase Fes/Fps

Background

FES (feline sarcoma oncogene) and Fer are the only two members of a unique family of cytoplasmic protein tyrosine kinases. FES and Fer contain a central Src homology-2 (SH2) domain and a carboxy-terminal tyrosine kinase catalytic domain. They are structurally distinguished from other members of cytoplasmic protein tyrosine kinase subfamilies by the presence of amino-terminal Fer/CIP4 homology and coiled-coil domains. FES was originally identified as an oncogene from avian and feline retroviruses. Human c-Fes has been implicated in myeloid, vascular endothelial and neuronal cell differentiation. FES has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Mutations may activate the FES kinase and thereby contribute to cancer. However, recent data strongly suggests that the c-FES protein-tyrosine kinase is a tumor suppressor rather than a dominant oncogene in colorectal cancer.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol FES
Entrez