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FES (FES feline sarcoma oncogene) has tyrosine-specific protein kinase activity which is required for cellular transformation maintenance. FES plays a role in regulation of cell attachment, cell spreading, cell differentiation and microtubule assembly as well as being involved in cell scattering. FES is known to have interactions with ERZ, NSF, EGFR, CSF2RB and RASA1. This protein is currently being studied for research on the following diseases and disorders: sarcoma, leukemia, colon cancer, neuronitis, hemangioma and hematopoiesis.