FCRLA/FCRLM1 Antibody (865910) [Alexa Fluor® 594]

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications Flow
Clone
865910
Clonality
Monoclonal
Host
Rat
Conjugate
Alexa Fluor 594
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.

FCRLA/FCRLM1 Antibody (865910) [Alexa Fluor® 594] Summary

Immunogen
E. coli-derived recombinant mouse FCRLA
Lys221-Lys352
Accession # Q920A9
Specificity
Detects mouse FCRLA in ELISA.
Source
N/A
Isotype
IgG2a
Clonality
Monoclonal
Host
Rat
Gene
FCRLA
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Intracellular Staining by Flow Cytometry 0.25-1 ug/10^6 cells
Application Notes
Flow Cytometry: Please use 0.25-1 ug of conjugated antibody per 10e6 cells.

Packaging, Storage & Formulations

Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
Buffer
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.
Preservative
0.09% Sodium Azide
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for FCRLA/FCRLM1 Antibody (865910) [Alexa Fluor® 594]

  • Fc receptor homolog expressed in B cells (FREB)
  • Fc receptor homolog expressed in B-cells
  • Fc receptor related protein X
  • Fc receptor-like A
  • Fc receptor-like and mucin-like 1
  • Fc receptor-related protein X
  • FCRL1
  • FCRLA
  • FCRLb
  • FCRLc1
  • FCRLc2
  • FCRLd
  • FCRLe
  • FCRLFc receptor-like protein
  • FCRLM1
  • FCRLX
  • FcRX
  • FREB
  • FREBFc receptor-like and mucin-like protein 1
  • MGC4595

Background

FCRLA (Fc Receptor-Like A; also known as FcRX and Fc receptor Homolog Expressed in B cells) is a 44 kDa intracellular member of the Fc gamma RI class, FcR family, Immunoglobulin Superfamily of molecules. It is associated with B lineage cells, and has been identified in virtually all splenic B cells, peritoneal B1b and B2 B cells, and immature through mature bone marrow B cells. Not all cells show equal expression patterns. In the spleen, weak FCRLA expression occurs in naïve follicular and marginal zone B cells, and increases with activation state. FcRLA is suggested to act as an ER chaperone during antibody maturation, and is known to bind to IgM, IgA, and IgG prior to their secretion. Mouse FCRLA is synthesized as a 34 kDa, 322 amino acid (aa) precursor that contains a 30 aa signal sequence, two C2‑type Ig‑like domains (aa 80-169 and 182-26), and a C-terminal poly-Proline region (aa 289-294). Although there is no traditional ER retention signal, a viable substitute is assumed to exist at the N-terminus of the mature molecule. FCRLA is believed to exist naturally as a monomer; however, disulfide-linkage can occur during experimental manipulation. While four potential isoform variants are reported, it is unclear if any are actually expressed. One shows an Ala insertion after Ala28, a second shows an AlaIle substitution for aa 20-22, a third contains that previous AlaIle substitution coupled to a deletion of aa 90-115, while a fourth utilizes an alternative start site at Met62. Over aa 221-352, mouse FCRLA shares 68% and 55% aa sequence identity with rat and human FCRLA, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 FAB7905U
Alexa Fluor 405 FAB7905V
Alexa Fluor 488 FAB7905G
Alexa Fluor 594 FAB7905T
Alexa Fluor 647 FAB7905R
Alexa Fluor 700 FAB7905N
Alexa Fluor 750 FAB7905S

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Bioinformatics

Gene Symbol FCRLA
Uniprot