NB100-65338 recognizes the human CD32 antigen, a 40kD glycoprotein that acts as a low affinity receptor for IgG (also known as Fc gamma RII). The antigen mediates several functions including endocytosis, activation of secretion, cytotoxicity and immunomodulation. CD32 is expressed by B cells, monocytes, granulocytes and platelets. Clone AT10 blocks the binding of IgG to Fc gamma RII.
Protein A purified
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This antibody does not work in Immunohistochemistry-Paraffin. This product contains sodium azide, removal by dialysis is recommended prior to use in functional assays. The epitope recognised by this antibody is reported to be sensitive to formaldehyde fixation and tissue processing. We recommend the use of acetone fixation for frozen sections.
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
0.09% Sodium Azide
Protein A purified
Alternate Names for Fc gamma RII/CD32 Antibody (AT10)
CD32Fc fragment of IgG, low affinity II, receptor for (CD32)
Fc fragment of IgG, low affinity IIb, receptor (CD32)
Fc fragment of IgG, low affinity IIb, receptor for (CD32)
Fc gamma RII
Fc gamma RIIb
IgG Fc receptor II-b
low affinity immunoglobulin gamma Fc region receptor II-b
CD32 is a receptor for the Fc region of complexed or aggregated immunoglobulins gamma. This is a low affinity receptor. It is Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B cells. Binding to this receptor results in down modulation of previous state of cell activation triggered via antigen receptors on B cells (BCR), T cells (TCR) or via another Fc receptor.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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