FANCD2 (Fanconi anemia group D2 protein) belongs to family of FANC proteins which includes several members such as FANC-A, -B, -C, -D1/BRCA2, -D2, -E, -F, -G, -I, -J/BRIP1, -L, -M and -N/PALB2. FANCD2 interacts with several proteins such as FANCE/FANCI, USP1, MEN1, BRCA1, BRCA2, BLM, MTMR15/FAN1 and DCLRE1B/Apollo. FANC proteins (-A, -B, -C, -D1, -D2, -E, -F, -G, -L) cooperate in FANC/BRCA pathway resulting in monoubiquitination of FANCD2 which then promotes BRCA2/FANCD1 loading onto chromatin for creating nuclear foci at DNA damage sites. It is involved in DNA double-strand breaks repair, both by homologous recombination and single-strand annealing. FANCD2 is required for maintenance of chromosomal stability and promotes accurate/efficient pairing of homologs during meiosis. FANCD2 may participate in S phase/G2 phase checkpoint activation upon DNA damage amd plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress. Defects in FANCD2 are a cause of Fanconi anemia complementation group D type 2 characterized by anemia, leukopenia and thrombopenia.
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FANCD2 and DNA damage repair Fanconi anemia (FA) is a genetically inherited disorder that yields cytogenetic instability, hypersensitivity to DNA crosslinking compounds and defective DNA repair. A variety of genes have been identified within the FA pathway that are referred t... Read full blog post.
FANCD2 (Fanconi anemia subunit D2 protein) Fanconi anemia (FANC) is a rare, autosomal-recessive genetic disorder that is a heterogeneous cancer susceptibility condition that manifests with a wide range of symptoms such as congenital malformations, deteriorating bone marrow failure, DNA-dama... Read full blog post.
FANCD2: DNA Repair and Beyond Fanconi anemia (FANC) is a heterogenous, autosomal-recessive cancer susceptibility genetic disorder that is characterized by a wide array of symptoms, including congenital defects, progressive bone marrow failure due to DNA-damage hypersensitivity, ch... Read full blog post.
NUP153 & 53BP1: A Novel DNA Repair Pathway Mediating DNA damage is a crucial process, and one of the most important cellular guards against cancer. In response to DNA damage, sophisticated cellular machinery is recruited to repair the breaks, and if it fails, the cell is committed to death. De... Read full blog post.
Fanconi Antibodies and Cancer Research We at Novus Biologicals have an extensive antibody databasedevoted to the 13 Fanconi anaemia complementation (FANC) genes, which are involved in the recognition and repair of damaged DNA.The core complex of 8 proteins (FANCA, B, C, E, F, G, L and M)... Read full blog post.