BRCA2 Products

Antibodies
BRCA2 Antibody (234403)
BRCA2 Antibody (234403)
MAB2476
Species: Hu
Applications: WB, IHC
Host: Mouse Monoclonal
BRCA2 Antibody
BRCA2 Antibody
NBP1-88361
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
BRCA2 Antibody (9D3)
BRCA2 Antibody (9D3)
NBP1-41187
Species: Hu
Applications: WB, IHC, IHC-P, IP
Host: Mouse Monoclonal
Proteins
BRCA2 Recombinant Protein
BRCA2 Recombinant Protein
H00000675-Q01
Species: Hu
Applications: WB, ELISA
BRCA2 Recombinant Protein Ant ...
BRCA2 Recombinant Protein Antigen
NBP1-88361PEP
Species: Hu
Applications: AC
RNAi
BRCA2 RNAi
BRCA2 RNAi
H00000675-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

BRCA 2 is localized to chromosome 13q12 - q13. Loss of heterozygosity of 13q is observed in 25% of sporadic breast tumors, which indicates that BRCA 2 might be a tumor suppressor gene. BRCA 2 confers only a low ovarian cancer risk. Reportedly, in MCF-10F (normal breast epithelial cell line) and MCF-7 (breast cancer cell line) cells the expression of BRCA 2 RNA lowers in G0 and early G1 phases then gets up-regulated at the G1 / S phase junction.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Product By Gene ID 675
Alternate Names
  • breast cancer type 2 susceptibility protein
  • GLM3
  • breast cancer susceptibility protein BRCA2
  • BROVCA2
  • breast cancer 2 tumor suppressor
  • FACD
  • breast and ovarian cancer susceptibility gene, early onset
  • Fanconi anemia group D1 protein
  • BRCA1/BRCA2-containing complex, subunit 2
  • FAD1
  • FANCD
  • FAD
  • FANCB
  • BRCC2
  • FANCD1Fanconi anemia, complementation group D1
  • PNCA2
  • breast cancer 2, early onset

Research Areas for BRCA2

Find related products by research area and learn more about each of the different research areas below.

Breast Cancer
Cancer

Bioinformatics Tool for BRCA2

Discover related pathways, diseases and genes to BRCA2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related BRCA2 Blog Posts

Check out the latest blog posts on BRCA2.
FANCD2 and DNA damage repair
Fanconi anemia (FA) is a genetically inherited disorder that yields cytogenetic instability, hypersensitivity to DNA crosslinking compounds and defective DNA repair. A variety of genes have been identified within the FA pathway that are referred t...    Read more.
Breast Cancer Infographic
Breast cancer is caused by malignant cells developing in breast tissue. It is the most commonly diagnosed cancer in women, but advancements in treatment options have seen the death rate decline since the 1990s. Common warning signs of breast cancer in...    Read more.
RAD51: The cell's 'Mr. Fix-it'
RAD51 is a recombinase protein encoded by RAD51 gene in humans. Human RAD51 family members are highly similar to bacterial RecA and yeast Rad51, both biochemically and structurally. It is a 339-amino acid protein that plays an important role in homolo...    Read more.
Breast Cancer and RAD51L1 Antibodies
In the United States, breast cancer is one of the most common cancers and the second leading cause of cancer related deaths in women. According to the American Cancer Society's most recent estimates for breast cancer in the United States, there are ab...    Read more.
Determining DMC1's role in Homologus Recombination
The DMC1 gene encodes a 36.7 kDa nuclear protein involved in meiotic homologous recombination. This recombinase is functionally related to the yeast RAD51 and E. coli RecA genes. In contrast to RAD51, which functions in both mitotic and meiotic recomb...    Read more.
Rad51 Antibody Reveals a Canine Model for Human Breast Cancer
Our antibody catalog includes an extensive range of Rad51 antibody reagents. Encoded by the RAD51 gene, the Rad51 protein plays a vital role in DNA repair, interacting with several other proteins, including BRCA1 and BRCA2, to effect homologous recomb...    Read more.
Industrial Chemicals, Tumour Suppressor Genes and the Need for More Research
Human cancer research is the largest research area in our antibody database, with new oncogenes and cell lines being added all the time.Cancer triggers come from many sources, with a worrying amount of evidence to suggest that chemicals we’re in con...    Read more.
Fanconi Antibodies and Cancer Research
We at Novus Biologicals have an extensive antibody databasedevoted to the 13 Fanconi anaemia complementation (FANC) genes, which are involved in the recognition and repair of damaged DNA.The core complex of 8 proteins (FANCA, B, C, E, F, G, L and M)...    Read more.
Read more BRCA2 related blogs.