FADD Antibody


Western Blot: FADD Antibody [NBP1-45552] - Analysis of FADD expression with Jurkat cell lysates (Lane 1, 2).

Product Details

Reactivity Hu, Mu, Rt, PmSpecies Glossary
Applications WB, IP
0.2 mg/ml

Order Details

FADD Antibody Summary

Synthetic peptide surrounding amino acid 128 of human FADD.
Immunogen affinity purified
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Packaging, Storage & Formulations

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA
0.01% Thimerosal
0.2 mg/ml
Immunogen affinity purified


  • Western Blot 0.5-4 ug/ml
  • Immunoprecipitation 1:10-1:500
Application Notes
The antibody detects an ~28 kDa band, corresponding to the expected molecular mass of FADD on immunoblots.

The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
23 kDa

Alternate Names for FADD Antibody

  • Fas (TNFRSF6)-associated via death domain
  • FAS-associated death domain protein
  • FAS-associating death domain-containing protein
  • GIG3
  • Growth-inhibiting gene 3 protein
  • Mediator of receptor induced toxicity
  • mediator of receptor-induced toxicity
  • MGC8528
  • MORT1
  • MORT1Fas-associating protein with death domain
  • protein FADD


Fas-associating protein with death domain (FADD) is an adaptor protein involved in the apoptosis induced by Fas and TNF-R1, and mitogen induced cell proliferation (1). FADD consists of death domain (DD) at the C-terminal and death effector domain (DED) at the N-terminal (2). DD interacts with Fas and TNF-R1, which exposes the DED portion on the FADD. Unmasked DED binds to the DED of pro-caspase-8, which activates the cysteine protease cascade (3). The development of autoimmune lymphoproliferative (lpr) diseases has been linked to inactivation of Fas-FADD interaction (4). Also, the deficiency in FADD can inhibit TRAIL-induced cell apoptosis.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies


Isotype Controls

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Research Areas for FADD Antibody (NBP1-45552)

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Blogs on FADD.

FADD - important initiator of death receptor-mediated apoptosis
FAS-associated death domain protein (FADD) is a 23 kDa adaptor protein involved in initiating apoptosis. FADD is best known for its involvement in extrinsic/death receptor-mediated apoptosis, but it is also involved in initiating necroptosis with ...  Read full blog post.

Caspase 9: The Suicidal Cell Whisperer
Cell death via apoptosis is a key cellular function triggered by the cell death receptor family and their ligands which signal through downstream adaptor molecules and the caspase protease family. Among the subclass of initiator caspases that include...  Read full blog post.

Contact Information

Product PDFs


Gene Symbol FADD

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