Applications: WB, ICC
Host: Mouse Monoclonal
Host: Goat Polyclonal
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Applications: WB, ELISA, PA
WB, ELISA, PA
Applications: B/N, Ctrl
Fas-associating protein with death domain (FADD) is an adaptor protein involved in the apoptosis induced by Fas and TNF-R1, and mitogen induced cell proliferation (1). FADD consists of death domain (DD) at the C-terminal and death effector domain (DED) at the N-terminal (2). DD interacts with Fas and TNF-R1, which exposes the DED portion on the FADD. Unmasked DED binds to the DED of pro-caspase-8, which activates the cysteine protease cascade (3). The development of autoimmune lymphoproliferative (lpr) diseases has been linked to inactivation of Fas-FADD interaction (4). Also, the deficiency in FADD can inhibit TRAIL-induced cell apoptosis.
|Product By Gene ID
- FAS-associated death domain protein
- Mediator of receptor induced toxicity
- protein FADD
- Growth-inhibiting gene 3 protein
- mediator of receptor-induced toxicity
- FAS-associating death domain-containing protein
- MORT1Fas-associating protein with death domain
- Fas (TNFRSF6)-associated via death domain
Bioinformatics Tool for FADD
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Related FADD Blog Posts
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|FADD - important initiator of death receptor-mediated apoptosis
FAS-associated death domain protein (FADD) is a 23 kDa adaptor protein involved in initiating apoptosis. FADD is best known for its involvement in extrinsic/death receptor-mediated apoptosis, but it is also involved in initiating necroptosis with ... Read more.
|Caspase 9: The Suicidal Cell Whisperer
Cell death via apoptosis is a key cellular function triggered by the cell death receptor family and their ligands which signal through downstream adaptor molecules and the caspase protease family. Among the subclass of initiator caspases that include... Read more.