FADD Products

Antibodies
FADD Antibody
FADD Antibody
NBP1-81831
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
FADD [p Ser194] Antibody (709 ...
FADD [p Ser194] Antibody (709736)
MAB7047
Species: Hu
Applications: WB, ICC
Host: Mouse Monoclonal
FADD Antibody
FADD Antibody
AF2938
Species: Hu
Applications: WB
Host: Goat Polyclonal
Antibody Pairs
FADD Antibody Pair
FADD Antibody Pair
H00008772-AP11
Species: Hu
Applications: S-ELISA
FADD Antibody Pair
FADD Antibody Pair
H00008772-AP12
Species: Hu
Applications: S-ELISA
Lysates
FADD Overexpression Lysate (N ...
FADD Overexpression Lysate (Native)
NBL1-10424
Applications: WB
FADD Overexpression Lysate (D ...
FADD Overexpression Lysate (Denatu...
H00008772-T01
Species: Hu
Applications: WB
Proteins
FADD Recombinant Protein
FADD Recombinant Protein
H00008772-P01
Species: Hu
Applications: WB, ELISA, PA
FADD Partial Recombinant Prot ...
FADD Partial Recombinant Protein
H00008772-Q01
Species: Hu
Applications: WB, ELISA, PA
FADD Recombinant Protein Anti ...
FADD Recombinant Protein Antigen
NBP1-81831PEP
Species: Hu
Applications: AC
RNAi
FADD RNAi
FADD RNAi
H00008772-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

Fas-associating protein with death domain (FADD) is an adaptor protein involved in the apoptosis induced by Fas and TNF-R1, and mitogen induced cell proliferation (1). FADD consists of death domain (DD) at the C-terminal and death effector domain (DED) at the N-terminal (2). DD interacts with Fas and TNF-R1, which exposes the DED portion on the FADD. Unmasked DED binds to the DED of pro-caspase-8, which activates the cysteine protease cascade (3). The development of autoimmune lymphoproliferative (lpr) diseases has been linked to inactivation of Fas-FADD interaction (4). Also, the deficiency in FADD can inhibit TRAIL-induced cell apoptosis.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Mouse
Mouse
Product By Gene ID 8772
Alternate Names
  • GIG3
  • FAS-associated death domain protein
  • Mediator of receptor induced toxicity
  • protein FADD
  • Growth-inhibiting gene 3 protein
  • mediator of receptor-induced toxicity
  • FAS-associating death domain-containing protein
  • MORT1Fas-associating protein with death domain
  • MGC8528
  • Fas (TNFRSF6)-associated via death domain

Research Areas for FADD

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Diabetes Research
Phospho-Specific
Tumor Suppressors

Bioinformatics Tool for FADD

Discover related pathways, diseases and genes to FADD. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related FADD Blog Posts

Check out the latest blog posts on FADD.
FADD - important initiator of death receptor-mediated apoptosis
FAS-associated death domain protein (FADD) is a 23 kDa adaptor protein involved in initiating apoptosis. FADD is best known for its involvement in extrinsic/death receptor-mediated apoptosis, but it is also involved in initiating necroptosis with ...    Read more.
Caspase 9: The Suicidal Cell Whisperer
Cell death via apoptosis is a key cellular function triggered by the cell death receptor family and their ligands which signal through downstream adaptor molecules and the caspase protease family. Among the subclass of initiator caspases that include...    Read more.
Read more FADD related blogs.