Exostosin-like 3/EXTL3 Antibody - BSA Free

Western Blot: Exostosin-like 3/EXTL3 Antibody [NBP2-16395] - Sample (30 ug of whole cell lysate) A: U87-MG 7. 5% SDS PAGE gel, diluted at 1:1000.

• Reactivity: Hu, Mu, Rt, Bv, Xp, Ze
• Applications: WB
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free

Exostosin-like 3/EXTL3 Antibody - BSA Free Summary

• Immunogen: Recombinant protein encompassing a sequence within the C-terminus region of human Exostosin-like 3/EXTL3. The exact sequence is proprietary.
• Localization: Endoplasmic reticulum membrane; Single-pass type II membrane protein
• Predicted Species: Mouse (100%), Rat (100%), Xenopus (96%), Zebrafish (95%), Bovine (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: EXTL3
• Purity: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot 1:500-1:3000
• Theoretical MW: 105 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Xenopus laevis (96%).

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: 0.1M Tris (pH 7), 0.1M Glycine, 20% Glycerol
• Preservative: 0.01% Thimerosal
• Purity: Antigen Affinity-purified

Alternate Names for Exostosin-like 3/EXTL3 Antibody - BSA Free

• botv
• DKFZp686C2342
• EC 2.4.1.223
• exostoses (multiple)-like 3
• Exostosin like 3
• Exostosin-like 3
• EXTL1L
• EXTL3
• EXTR1BOTV
• EXT-related protein 1
• Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase
• Hereditary multiple exostoses gene isolog
• KIAA0519
• Multiple exostosis-like protein 3
• Putative tumor suppressor protein EXTL3
• reg receptor
• REG
• REGR
• RPR

Background

EXTL3, also referred to as Exostosin-like 3, is a glycosyltransferase and a critical player in the control of keratinocyte proliferation and differentiation via its interaction with REG3A. EXTL3 is 919 amino acids in length and approximately 105kDa. Current research surrounding EXTL3 has shown a possible link with several diseases and disorders such as colorectal cancer, HIV, hepatitis, gonorrhea, syphilis, exostosis, pancreatitis and rheumatic aortic stenosis. EXTL3 has also been shown to interact with Fyn, Crk, Phospholipase C gamma 1, PI 3 Kinase p85 alpha, and PEPP2 in pathways such as Glycosaminoglycan biosynthesis, heparan sulfate biosynthesis, the activation of Chaperones by IRE1alpha, and protein metabolism pathways.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects.  For more information go to www.P65Warnings.ca.gov.

Bioinformatics

• Gene Symbol: EXTL3
• Uniprot:
  • O43909()