ERR gamma/NR3B3 Antibody

Immunohistochemistry-Paraffin: ERR gamma/NR3B3 Antibody [NLS2400] - Analysis of anti-ERR Gamma antibody with human kidney, diabetes.

Immunohistochemistry-Paraffin: ERR gamma/NR3B3 Antibody [NLS2400] - Analysis of anti-ERR Gamma antibody with kidney.

Immunohistochemistry-Paraffin: ERR gamma/NR3B3 Antibody [NLS2400] - Analysis of anti-ERR Gamma antibody with breast cancer at 34 ug/ ml.

Product Discontinued

ERR gamma/NR3B3 Antibody Summary

• Immunogen: Synthetic 16 aa peptide from near N-terminus of human ERR gamma/NR3B3.
• Specificity: Human ESRRG / ERR3. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Predicted Species: Opossum (100%), Fish (94%), Orangutan (100%), Turkey (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: ESRRG
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 34 - 68 ug/ml

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (100%), Marmoset (100%).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for ERR gamma/NR3B3 Antibody

• DKFZp781L1617
• ERR gamma
• ERR gamma-2
• ERR3
• ERRG2
• ERRgamma
• ESRRG
• Estrogen receptor-related protein 3
• estrogen-related receptor gamma
• FLJ16023
• KIAA0832
• NR3B3
• Nuclear receptor subfamily 3 group B member 3

Background

Estrogen receptor-related receptor (ERR gamma), a NR3 Steroid Receptor, has been suggested to affect differentiation of the brain, heart, and kidney. ERR gamma binds as a monomer to an extended half-site of the ERRE type (TCAAGGTCA). ERR gamma has been shown to interact with PGC-1 alpha and has been implicated in the regulation of mitochondrial energy metabolism. In humans, ERR gamma pre-mRNA undergoes extensive alternative splicing at the 5 end, yielding at least six mRNA splice variants and two protein isoforms that differ by 23 amino acids in the N terminus. ERR gamma has been shown to be overexpressed in breast tumors, and its expression is correlated with levels of ErbB4, a likely indicator of preferred clinical course. As a result, ERR gamma has been suggested to be a potential biomarker for favorable clinical course and, possibly, hormonal sensitivity, and as a candidate target for therapeutic development. ERR gamma expression at the mRNA and protein levels is isoform- and tissue-specific in humans. ERR gamma expression has been documented in human heart, brain, placenta, skeletal muscle, kidney, pancreas, spleen, prostate, testis, and small intestine. ESTs have been isolated from human tissue libraries, including cancerous fetus, uterus, lung, breast, head/neck, colon, skin, eye, adrenal, and breast, and normal placenta, kidney, brain, eye, pineal, ear, and heart.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ESRRG
• Entrez:
  • 2104(Human)