EMMPRIN/CD147 Antibody (MEM-M6/2)

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Product Details

Summary
Reactivity Hu, PoSpecies Glossary
Applications Flow, IHC, IHC-P, CyTOF-ready
Clone
MEM-M6/2
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
1.0 mg/ml

EMMPRIN/CD147 Antibody (MEM-M6/2) Summary

Immunogen
A soluble recombinant form of CD147, CD147Rg, which consists of the cDNA coding for the entire extracellular region of CD147 fused to the DNA coding for the hinge region, CH2 and CH3 domain of human IgG1.
Epitope
This antibody recognises extracellular Ig domain D1 of CD147 antigen.
Localization
Cell Membrane
Specificity
The antibody MEM-M6/2 recognizes extracellular Ig domain D1 of CD147 (Neurothelin), a 50-60 kDa type I transmembrane glycoprotein primarily expressed on all leukocytes, red blood cells, platelets and endothelial cells; it is not expressed by resting lymphocytes. The antibody MEM-M6/1 is a high-affinity antibody capable of binding to unstimulated peripheral blood T cells.
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
BSG
Purity
Protein A purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 4 ug/ml
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 10 ug/ml
  • CyTOF-ready
Positive Control
EMMPRIN/CD147 Lysate (NBL1-08036)

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
PBS (pH 7.4)
Preservative
15mM Sodium Azide
Concentration
1.0 mg/ml
Purity
Protein A purified

Alternate Names for EMMPRIN/CD147 Antibody (MEM-M6/2)

  • 5F7
  • basigin (Ok blood group)
  • Basigin
  • BSG
  • CD147 antigen
  • CD147
  • Collagenase stimulatory factor
  • EMMPRIN
  • EMMPRINTCSF
  • Extracellular matrix metalloproteinase inducer
  • Leukocyte activation antigen M6
  • M6
  • OK blood group antigen
  • OK
  • Tumor cell-derived collagenase stimulatory factor

Background

CD147 plays a pivotal role in spermatogenesis, embryo implantation, neural network formation and tumor progression. It stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). CD147 may target monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to plasma membranes of retinal pigment epithelium and neural retina. CD147 also seems to be a receptor for oligomannosidic glycans. In vitro, it promotes outgrowth of astrocytic processes. CD147 forms homooligomers in a cis-dependent manner on the plasma membrane. It forms a complex with MMP1 at the tumor cell surface. CD147 interacts with SLC16A1 and SLC1A3; probably a BSG dimer is associated with a monocarboxylate transporter dimer. CD147 also interacts with ATP1B2, MAG and L1CAM.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 405 Labeled NB500-561AF405
Alexa Fluor 488 Labeled NB500-561AF488
Alexa Fluor 647 Labeled NB500-561AF647
Alexa Fluor 700 Labeled NB500-561AF700
Allophycocyanin Labeled NB500-561APC
DyLight 350 Labeled NB500-561UV
DyLight 405 Labeled NB500-561V
DyLight 488 Labeled NB500-561G
DyLight 550 Labeled NB500-561R
DyLight 680 Labeled NB500-561FR
DyLight 755 Labeled NB500-561IR
PE Labeled NB500-561PE
PerCP Labeled NB500-561PCP

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Bioinformatics

Gene Symbol BSG
Entrez