EMMPRIN/CD147 Products

Description

CD147 plays a pivotal role in spermatogenesis, embryo implantation, neural network formation and tumor progression. It stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). CD147 may target monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to plasma membranes of retinal pigment epithelium and neural retina. CD147 also seems to be a receptor for oligomannosidic glycans. In vitro, it promotes outgrowth of astrocytic processes. CD147 forms homooligomers in a cis-dependent manner on the plasma membrane. It forms a complex with MMP1 at the tumor cell surface. CD147 interacts with SLC16A1 and SLC1A3; probably a BSG dimer is associated with a monocarboxylate transporter dimer. CD147 also interacts with ATP1B2, MAG and L1CAM.

Bioinformatics

Entrez	12215 Mouse 25246 Rat 682 Human
Uniprot	NM_001728 Human NM_198589 Human NM_198591 Human NP_001070652 Mouse NP_001719 Human NP_940991 Human NP_940991.1 Human P26453 Rat P35613 Human P35613 Human Q54A51 Human
Product By Gene ID	682
Alternate Names	5F7 basigin (Ok blood group) basigin CD147 antigen CD147 Collagenase stimulatory factor EMMPRINTCSF Extracellular matrix metalloproteinase inducer Leukocyte activation antigen M6 M6 OK blood group antigen OK Tumor cell-derived collagenase stimulatory factor

Research Areas for EMMPRIN/CD147

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Cancer
Signal Transduction
Vision

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