Elastin Antibody

• Reactivity: Hu
• Applications: ELISA, IHC, IHC-P
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Concentration: 5 mg/ml

Elastin Antibody Summary

• Immunogen: Native
• Localization: Secreted; extracellular space, extracellular matrix.
• Specificity: 100% with beta elastin at dilution of 1/6K. Cross reacts with alpha elastin from cow.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: ELN
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin

Reactivity Notes

Human. May react with Tree shrew.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2)
• Preservative: 0.1% Sodium Azide
• Concentration: 5 mg/ml
• Purity: Protein G purified

Alternate Names for Elastin Antibody

• elastin
• FLJ38671
• FLJ43523
• SVAS
• tropoelastin
• WBS
• WS

Background

Elastin is a protein in connective tissue that is elastic and allows many tissues in the body to resume their shape after stretching or contracting. Elastin helps skin to return to its original position when it is poked or pinched. Elastin is also an important load-bearing tissue in the bodies of mammals and used in places where mechanical energy is required to be stored. Elastin is particularly abundant in large elastic blood vessels such as the aorta. It is also very important in the lungs, elastic ligaments, the skin, the bladder, and elastic cartilage. Elastin is composed largely of glycine, proline, and other hydrophobic residues and contains multiple lysine-derived crosslinks, such as desmosines, which link the individual polypeptide chains into a rubberlike network. The hydrophobic regions of the chains, between the crosslinks, are highly mobile. The hydrophobic and crosslinking domains are coded by separate, small (27 to 114 bp) exons that are separated by large introns. The initial translation product is a 72,000-dalton polypeptide, designated tropoelastin. Elastin is made by linking many soluble tropoelastin protein molecules, in a reaction catalyzed by lysyl oxidase, to make a massive insoluble, durable cross-linked array.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ELN
• Entrez:
  • 2006(Human)