EAAT1/GLAST-1/SLC1A3 Antibody Blocking Peptide

• Reactivity: Rt
• Applications: AC
• Concentration: 1 mg/ml

EAAT1/GLAST-1/SLC1A3 Antibody Blocking Peptide Summary

• Specificity: This peptide is specific for NB100-1869 only.
• Protein/Peptide Type: Antibody Blocking Peptide
• Gene: SLC1A3

Applications/Dilutions

• Dilutions:
  • Antibody Competition
• Application Notes: This peptide is useful as a blocking peptide for NB100-1869. For further blocking peptide related protocol, click here.

Packaging, Storage & Formulations

• Storage: Store at -80C. Avoid freeze-thaw cycles.
• Buffer: Peptide dissolved in dH20. Contains no BSA.
• Preservative: No Preservative
• Concentration: 1 mg/ml

Alternate Names for EAAT1/GLAST-1/SLC1A3 Antibody Blocking Peptide

• EA6
• EA6FLJ25094
• EAAT1
• EAAT1GLAST-1
• excitatory amino acid transporter 1
• GLAST1
• GLAST-1
• GLASTGLAST1
• SLC1A3
• Sodium-dependent glutamate/aspartate transporter 1
• solute carrier family 1 (glial high affinity glutamate transporter), member 3
• Solute carrier family 1 member 3

Background

Human excitatory amino acid transporters (EAATs) are members of a family of high affinity sodium-dependent transporter molecules that regulate neurotransmitter concentrations at the excitatory glutamatergic synapses of the mammalian central nervous system. It is believed that these proteins reduce extracellular glutamate concentration, thereby modulating synaptic signaling. In addition, EAATs may also be important for the prevention of glutamate excitotoxicity. EAAT1 is prominently expressed in the frontal cortex, hippocampus and basal ganglia and is also reported to be found in heart, placenta, lung and striated muscle. EAAT1 shares some pharmacological similarities with EAAT3 and both are potent antagonists that appear to specifically block transport mediated by EAAT2. EAAT1 transports L-glutamate and also L- and D-aspartate, acting as a symport by co-transporting sodium. EAAT1 is essential for terminating the postsynaptic action of glutamate, by rapidly removing released glutamate from the synaptic cleft.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Bioinformatics

• Gene Symbol: SLC1A3