EAAT1/GLAST-1/SLC1A3 Products

Description

Human excitatory amino acid transporters (EAATs) are members of a family of high affinity sodium-dependent transporter molecules that regulate neurotransmitter concentrations at the excitatory glutamatergic synapses of the mammalian central nervous system. It is believed that these proteins reduce extracellular glutamate concentration, thereby modulating synaptic signaling. In addition, EAATs may also be important for the prevention of glutamate excitotoxicity. EAAT1 is prominently expressed in the frontal cortex, hippocampus and basal ganglia and is also reported to be found in heart, placenta, lung and striated muscle. EAAT1 shares some pharmacological similarities with EAAT3 and both are potent antagonists that appear to specifically block transport mediated by EAAT2. EAAT1 transports L-glutamate and also L- and D-aspartate, acting as a symport by co-transporting sodium. EAAT1 is essential for terminating the postsynaptic action of glutamate, by rapidly removing released glutamate from the synaptic cleft.

Bioinformatics

Entrez	20512 Mouse 29483 Rat 6507 Human
Uniprot	AAH37310 Human NP_001160167 Human NP_004163.3 Human P24942 Rat P43003 Human
Product By Gene ID	6507
Alternate Names	EA6FLJ25094 EAAT1GLAST-1 excitatory amino acid transporter 1 GLASTGLAST1 Sodium-dependent glutamate/aspartate transporter 1 solute carrier family 1 (glial high affinity glutamate transporter), member 3 Solute carrier family 1 member 3

Research Areas for EAAT1/GLAST-1/SLC1A3

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Cellular Markers