DUOX2 Antibody [DyLight 680]

• Reactivity: Hu, Mu, Rt, Po, Ca
• Applications: WB, ICC/IF, IHC, Mycoplasma
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: DyLight 680

DUOX2 Antibody [DyLight 680] Summary

• Description: This conjugate is made on demand and is not held in inventory. Each order represents a unique lot. All conjugates are generated using validated conjugation protocols and meet strict degree of labeling (F/P) specifications; additional information is available upon request. The antibody concentration is provided on the individual product label.
  
  For specialized conjugation needs, like large quantities, specific concentrations, and defined F/P ratios, bulk and custom antibody conjugation services are available.
• Immunogen: Synthetic peptide made to an internal portion of human DUOX2 (within residues 400-500). [Swiss-Prot# Q9NRD8]
• Localization: Apical cell membrane; Multi-pass membrane protein. Note: Localizes to the apical membrane of epithelial cells.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: DUOX2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Knockdown Validated
  • Western Blot
• Application Notes: Recommended applications are based on validated applications from the unconjugated base product NB110-61576. This conjugated antibody is not kept in inventory and is made to order using validated conjugation protocols.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Immunogen affinity purified

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for DUOX2 Antibody [DyLight 680]

• dual oxidase 2
• dual oxidase-like domains 2
• EC 1.11.1.-
• EC 1.6.3.1
• flavoprotein NADPH oxidase
• Large NOX 2
• LNOX2P138(TOX)
• Long NOX 2
• NADH/NADPH thyroid oxidase p138-tox
• NADPH oxidase/peroxidase DUOX2
• NADPH thyroid oxidase 2
• nicotinamide adenine dinucleotide phosphate oxidase
• NOXEF2
• p138 thyroid oxidase
• P138-TOX
• THOX2TDH6
• Thyroid oxidase 2

Background

Dual oxidase 2 (DUOX2), a reduced NAD phosphate:O2 oxidoreductase flavoprotein, plays a critical role in the synthesis of thyroid hormones by providing thyroperoxidase with hydrogen peroxide, which is required for hormone synthesis at the apical plasma membrane. The discovery of DUOX-2 as a novel source of hydrogen peroxide in the digestive tract, particularly in the cecum and colon, makes it a new candidate mediator of physiopathological processes.

DUOX2 antibodies may be useful tools for thyroid hormone synthesis, hormonal regulation disorders, and certian types of cancer.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

FAQs for DUOX2 Antibody (NB110-61576FR). (Showing 1 - 1 of 1 FAQ).

1. Hi, I am looking for an antibody to human DUOX2 that will work on human formalin fixed paraffin embedded sections. I notice from your website that you have several recommended for WB and wondered if you have any experience of their use in other areas?
   • At this time we do not have an antibody for DUOX2 that works in IHC paraffin embedded sections. If you choose to try one in this application we have our Innovator's Reward program where we reward our customers for trying antibodies in previously untested applications and species.

Bioinformatics

• Gene Symbol: DUOX2