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Dopamine D2R/DRD2 Antibody

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Immunohistochemistry-Paraffin: Dopamine D2 R/DRD2 Antibody [NLS1403] - Analysis of anti-DRD2 antibody with human brain, neurons and glia at 3 ug/ml.
Immunohistochemistry-Paraffin: Dopamine D2 R/DRD2 Antibody [NLS1403] - Analysis of anti-DRD2 antibody with human brain, neurons and glia at 3 ug/ml.

Product Details

Summary
Reactivity Hu, Pm, Pm, Pm, RbSpecies Glossary
Applications IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml

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Dopamine D2R/DRD2 Antibody Summary

Immunogen
Synthetic 19 amino acid peptide from 3rd cytoplasmic domain of human Dopamine D2R/DRD2.
Localization
Plasma membrane
Specificity
Human DRD2. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except ZNF57 (42%).
Predicted Species
Monkey (95%), Primate (95%), Chimpanzee (100%), Rabbit (95%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
DRD2
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 5 - 10 ug/ml
Control
Dopamine D2R/DRD2 Overexpression Lysate
Publications
Read Publications using
NLS1403 in the following applications:

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Marmoset (100%), Gibbon (95%), Canine (89%), Bovine (89%), Equine (89%), Porcine (89%), Mouse (84%), Rat (84%), Bat (84%), Hamster (84%).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.1% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Dopamine D2R/DRD2 Antibody

  • D(2) dopamine receptor
  • D2DR
  • D2R
  • Dopamine D2 R
  • Dopamine D2 receptor
  • Dopamine D2R
  • dopamine receptor D2 isoform
  • dopamine receptor D2
  • DRD2
  • seven transmembrane helix receptor

Background

The DRD2 Dopamine Receptor is involved in the neuromodulation of appetitive behaviors. DRD2 may be linked to alcoholism and other substance-use disorders. Mutations in DRD2 in mice lead to the suppression of reward behavior with morphine and to the reduction of spontaneous movements, a phenotype resembling Parkinson's disease. Three alternatively spliced isoforms have been identified. DRD2 has been reported to be expressed in various regions of the brain, as well as in aorta, artery, eye, and spinal cord. ESTs have been isolated from normal pituitary and in brain, colon, lung, pancreas, and skeletal muscle cancer libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Flow Cytometry: 5-HT2A Antibody [NBP2-26091] - Flow cytometric analysis of paraformaldehyde fixed A549 cells (blue line), permeabilized with 0.5% Triton. Primary incubation 1hr (10 ug/mL) followed by Alexa Fluor 488 secondary antibody (1 ug/mL). IgG control: Unimmunized goat IgG (black line) followed by Alexa Fluor 488 secondary antibody.
(1 Publication)
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Publications for Dopamine D2R/DRD2 Antibody (NLS1403)(2)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: IHC-P.


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Control Lysate(s)

Dopamine D2R/DRD2 Overexpression Lysate

Secondary Antibodies

 

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Bioinformatics

Gene Symbol DRD2
Entrez
Uniprot