DISC1 Antibody


Immunocytochemistry/ Immunofluorescence: DISC1 Antibody [NB110-40775] - DISC1 antibody was tested in PC-12 cells at 1:100 with Dylight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and ...read more
Immunohistochemistry: DISC1 Antibody [NB110-40775] - Staining of DISC1 in mouse brain neurons, glial cells, and white matter. 40X

Product Details

Reactivity Mu, RtSpecies Glossary
Applications ICC/IF, IHC, IHC-Fr, IHC-P
0.95 mg/ml

DISC1 Antibody Summary

A synthetic peptide made to an internal region (within residues 700-800) of the mouse DISC1 protein. [Swiss-Prot# Q811T9]
DISC-1 localizes to the nucleus, whereas mutant DISC-1 localization occurs mainly in the cytoplasm. It co-localizes with the following organelle structure antibodies: PD1, calnexin, GIANTIN, 58K, Rab4, LAMP-1, RAP1, KDEL, and catalase.
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Packaging, Storage & Formulations

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Tris-glycine, 150 mM NaCl
0.05% Sodium Azide
0.95 mg/ml
Immunogen affinity purified


Application Notes
This DISC1 antibody is useful for Immunocytochemistry/Immunofluorescence and Immunohistochemistry paraffin embedded sections. Use in Immunohistochemistry-Frozen reported in scientific literature (PMID 24560582) The theoretical molecular weight of DISC1 is ~90 kDa. Preliminary Western Blot studies have been performed with this antibody, where several non-specific bands are seen. Due to alternative splicing, DISC1 may also run at ~75 and 100 kDa. In ICC/IF, cytoplasmic staining was observed in PC12 cells.
Control Peptide
DISC1 Peptide (NB110-40775PEP)
Read Publication using
NB110-40775 in the following applications:

Reactivity Notes

Mouse and rat. Immunogen sequence has 42% homology to human.

Alternate Names for DISC1 Antibody

  • C1orf136
  • disrupted in schizophrenia 1 protein
  • disrupted in schizophrenia 1
  • FLJ13381
  • FLJ21640
  • FLJ25311
  • FLJ41105
  • KIAA0457
  • SCZD9


DISC1 (Disrupted in Schizophrenia 1) is a well known risk genes for psychiatric disorders including schizophrenia, major depression, bipolar disorder, and autism. DISC1 protein localize to cytoskeleton-rich regions in cells, including the centrosome, base of primary cilia, axon and dendritic shafts and spines. For serving its multiple functions, DISC1 interacts with CCDC88A, GSK3B, PCNT, tubulin alpha, ACTN2, ANKHD1, ATF4, ATF5, CEP63, EIF3S3, MAP1A, NDEL1, PAFAH1B1, RANBP9, SPTBN4, SYNE1, TRAF3IP1, CHCHD6 and NDEL1. DISC1 interaction with microtubules TRAF3IP1. In neurogenesis regulation, DISC1 is essential for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development as well as in adult dentate gyrus of hippocampus. DISC1 modulates GSK3Beta activity and CTNNB1 abundance for acting as positive regulator of WNT-mediated neural progenitor proliferation. DISC1 can modulate AKT-mTOR signaling for controlling the neuron positioning, dendritic development and synapse formation which ultimately regulate newborn neurons integration during adult neurogenesis and can regulate the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Moreover, DISC1 is implicated in microtubule network formation, regulation of functional biology of centrosome as well as primary cilia, neuronal migration and microtubule mediated transport.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customers Who Viewed This Item Also Viewed...

Species: Hu
Applications: WB, IHC, IHC-P
Species: Hu, Mu
Applications: WB, Flow, ICC/IF, IHC, IHC-P
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
Species: Hu, Mu
Applications: WB, Flow, ICC/IF, IHC, IHC-P
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P
Species: Hu
Applications: WB, IHC, IHC-P
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P
Species: Hu
Applications: WB, PEP-ELISA
Species: Hu
Applications: WB, IHC, IHC-P
Species: Hu
Applications: WB, Flow, ICC/IF, IHC, IHC-P
Species: Hu, Mu, Rt
Applications: WB, IHC, IHC-P
Species: Hu, Mu, Rt
Applications: WB, Simple Western, ICC, ICFlow
Species: Hu, Mu, Rt
Applications: WB, ICC/IF
Species: Hu
Applications: WB, Simple Western, ICC
Species: Hu
Applications: WB, IHC, IHC-P
Species: Hu
Applications: ICC/IF, IHC, IHC-P, IP
Species: Hu, Mu, Rt
Applications: WB, Flow, ICC/IF, IP
Species: Mu, Rt
Applications: ICC/IF, IHC, IHC-Fr, IHC-P

Publications for DISC1 Antibody (NB110-40775)(1)

We have publications tested in 1 confirmed species: Rat.

We have publications tested in 1 application: IHC-Fr.

Filter By Application
All Applications
Filter By Species
All Species

Reviews for DISC1 Antibody (NB110-40775) (0)

There are no reviews for DISC1 Antibody (NB110-40775). By submitting a review earn points towards our Rewards Program.
  • 250 points for product review
  • 500 additional points for an image with your product review
  • Double points (500) if you are the first to review this product
  • Double points (1000) if you are the first to review this product with an image

Product General Protocols

Video Protocols

ICC/IF Video Protocol

FAQs for DISC1 Antibody (NB110-40775) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Secondary Antibodies


Isotype Controls

Other Available Formats

Alexa Fluor (R) 405 Labeled NB110-40775AF405
Alexa Fluor (R) 488 Labeled NB110-40775AF488
Alexa Fluor (R) 647 Labeled NB110-40775AF647
Alexa Fluor (R) 700 Labeled NB110-40775AF700
Biotin Labeled NB110-40775B
DyLight 405 Labeled NB110-40775V
DyLight 488 Labeled NB110-40775G
DyLight 550 Labeled NB110-40775R
DyLight 650 Labeled NB110-40775C
FITC Labeled NB110-40775F
HRP Labeled NB110-40775H

Additional DISC1 Antibody Products

Related Products by Gene

Bioinformatics Tool for DISC1 Antibody (NB110-40775)

Discover related pathways, diseases and genes to DISC1 Antibody (NB110-40775). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for DISC1 Antibody (NB110-40775)

Discover more about diseases related to DISC1 Antibody (NB110-40775).

Pathways for DISC1 Antibody (NB110-40775)

View related products by pathway.

PTMs for DISC1 Antibody (NB110-40775)

Learn more about PTMs related to DISC1 Antibody (NB110-40775).

Research Areas for DISC1 Antibody (NB110-40775)

Find related products by research area.

Blogs on DISC1.

Calnexin - an ER chaperone that folds the cell's glycoproteins
Calnexin is an abundant 90kDa chaperone protein that resides in the membrane of the endoplasmic reticulum. Calnexin and the related calreticulin protein function together to ensure the proper folding of glycoproteins. By binding to partially folded...  Read full blog post.

Contact Information

Product PDFs


Gene Symbol DISC1

Customer Resources

Novus Review - Submit your review and earn rewards points which can be used for merchandise & discounts.
Risk Free Testing - Test on a species/application not listed above to receive a full credit towards a future purchase.

Novus' Quality Guarantee - Novus guarantees that every product we sell will work in the application and species listed on our website and datasheets.

Submit your question on NB110-40775 below.
During business hours, we will respond to your email within 24 hours. For any questions submitted on the weekend, a response will be received on Monday.
For immediate assistance during business hours M- F (excluding major holidays), please contact us.
Ask a Scientist - We have a lab full of white coats just waiting for your scientific questions and concerns.

Customers Who Bought This Also Bought