DEP-1/CD148 Antibody (MEM-CD148/05)

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, CyTOF-ready
Clone
MEM-CD148/05
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
1.0 mg/ml

DEP-1/CD148 Antibody (MEM-CD148/05) Summary

Immunogen
Human recombinant CD148 (amino acids 1-444).
Specificity
The mouse monoclonal antibody MEM-CD148/05 recognizes CD148, a highly glycosylated up to 250 kDa receptor-like protein tyrosin phosphatase expressed mainly in lymphocytes, myeloid cells and epithelial cells.
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
PTPRJ
Purity
Protein A purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 1:50-1:250
  • CyTOF-ready

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
PBS (pH 7.4)
Preservative
15mM Sodium Azide
Concentration
1.0 mg/ml
Purity
Protein A purified

Alternate Names for DEP-1/CD148 Antibody (MEM-CD148/05)

  • CD148 antigen
  • CD148
  • Density-enhanced phosphatase 1
  • DEP1
  • DEP-1
  • DEP1EC 3.1.3.48
  • HPTP eta
  • HPTPeta
  • HPTP-eta
  • human density enhanced phosphatase-1
  • protein tyrosine phosphatase, receptor type, J polypeptide
  • protein tyrosine phosphatase, receptor type, J
  • Protein-tyrosine phosphatase eta
  • Protein-tyrosine phosphatase receptor type J
  • PTPRJ
  • receptor-type tyrosine-protein phosphatase eta
  • R-PTP-ETA
  • R-PTP-J
  • SCC1
  • susceptibility to colon cancer 1, mouse, homolog of

Background

CD148 (also known as HPTP-eta or DEP-1) is a transmembrane protein tyrosin phosphatase containing eight fibronectin type III extracellular domains. This protein is known to inhibit transduction of mitogenic signals in non-hematopoietic cells (fibroblasts, epithelial cells), and signal transduction downstream of T cell receptor, however, it also augments immunoreceptor signaling in B cells and macrophages via dephosphorylating C-terminal tyrosine of Src-family tyrosine kinases. CD148 expression increases after in vitro activation of peripheral blood leucocytes. It can be also used as marker of the most mature human thymocytes, and leukemic cells corresponding to this stadium of thymocyte differentiation. In contrast, in mice the CD148 expression sharply drops through the double positive stage to the single positive thymocytes.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 405 Labeled NBP2-21790AF405
Alexa Fluor 488 Labeled NBP2-21790AF488
Alexa Fluor 647 Labeled NBP2-21790AF647
Alexa Fluor 700 Labeled NBP2-21790AF700
Allophycocyanin Labeled NBP2-21790APC
DyLight 350 Labeled NBP2-21790UV
DyLight 405 Labeled NBP2-21790V
DyLight 488 Labeled NBP2-21790G
DyLight 680 Labeled NBP2-21790FR
DyLight 755 Labeled NBP2-21790IR
PE Labeled NBP2-21790PE
PerCP Labeled NBP2-21790PCP

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Bioinformatics Tool for DEP-1/CD148 Antibody (NBP2-21790)

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Diseases for DEP-1/CD148 Antibody (NBP2-21790)

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PTMs for DEP-1/CD148 Antibody (NBP2-21790)

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Bioinformatics

Gene Symbol PTPRJ
Entrez