DEP-1/CD148 Products

Description

PTPRJ is encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Bioinformatics

Entrez	5795 Human
Uniprot	NM_002843 Human NP_002834 Human
Product By Gene ID	5795
Alternate Names	CD148 antigen CD148 Density-enhanced phosphatase 1 DEP-1 DEP1EC 3.1.3.48 HPTP eta HPTPeta human density enhanced phosphatase-1 protein tyrosine phosphatase, receptor type, J polypeptide protein tyrosine phosphatase, receptor type, J Protein-tyrosine phosphatase eta Protein-tyrosine phosphatase receptor type J receptor-type tyrosine-protein phosphatase eta R-PTP-eta R-PTP-ETA R-PTP-J SCC1 susceptibility to colon cancer 1, mouse, homolog of

Research Areas for DEP-1/CD148

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Protein Phosphatase