Immunohistochemistry: Defensin alpha 5 Antibody (8C8) [NB110-60002] - Human skeletal muscle myocytes showing moderate nuclear and faint cytoplasmic staining.
Flow Cytometry: Defensin alpha 5 Antibody (8C8) [NB110-60002] - Intracellular flow cytometric staining of 1 x 10^6 MCF-7 cells using Defensin alpha 5 antibody (dark blue). Isotype control shown in orange. An antibody ...read more
This Defensin alpha 5 antibody is useful for Immunohistochemistry paraffin embedded sections, Western blot and Immunocytochemistry/Immunofluorescence. Dot Blot and ELISA were reported in scientific literature. Use in Immunohistochemistry-Frozen reported in scientific literature (PMID: 30612153). The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
10 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Tris-Glycine and 0.15M NaCl
0.05% Sodium Azide
Protein G purified
Alternate Names for Defensin alpha 5 Antibody (8C8)
DEF5defensin, alpha 5, preproprotein
Defensin alpha 5
Defensin, alpha 5
defensin, alpha 5, Paneth cell-specific
Defensins are a kind of endogenous antimicrobial peptide enriched with cysteine/arginine and are widely distributed in internal organs wherein they are recognized as defenders against invasion by pathogenic organisms. Human alpha-defensins (human alpha-defensins 5, -6, and human neutrophil peptides-1, -2, -3, -4) are a class of small antimicrobial peptides with well characterized antibacterial activity against both Gram +ve as well as Gram-ve bacteria, and certain viruses such as such as HSV, HPV, adenovirus and polyoma virus. Human alpha-defensin 5 (HD5) is a 32 amino acids long protein that shares a common structural feature of alpha-defensin family characterized by three-stranded anti-parallel beta-sheets stabilized by three intra-molecular disulfide bridges. HD5 is primarily expressed in small intestinal Paneth cells or epithelial cells of urino-genital tract, and it is found in cytoplasmic vesicle/secretory vesicle or in secreted form. Peptides HD5(20-94), HD5(23-94) and HD5(29-94) are found within tissues among which HD5(20-94) is the predominant intracellular form. In extracellular milieu, peptides HD5(56-94) and HD5(63-94) are found and among these two peptides, HD5 (63-94) is the most abundant form.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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