Dectin-2/CLEC6A Antibody (3D1) - Azide Free

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Western Blot: Dectin-2/CLEC6A Antibody (3D1) - Azide Free [NBP2-36486] - Analysis of Dectin-2 in human heart lysate in the 1) absence and 2) presence of immunizing peptide, 3) mouse heart lysate, 4) rat heart lysate and ...read more
Immunohistochemistry: Dectin-2/CLEC6A Antibody (3D1) - Azide Free [NBP2-36486] - Normal human spleen tissue stained with Dectin-2 antibody (5 ug/mL), peroxidase-conjugate and DAB chromogen. Human tissue TMA was used for ...read more
Flow Cytometry: Dectin-2/CLEC6A Antibody (3D1) - Azide Free [NBP2-36486] - An intracellular stain was performed on THP-1 cells with Dectin-2/CLEC6A (3D1) antibody NBP2-27159AF488 (blue) and a matched isotype control ...read more
Flow Cytometry: Dectin-2/CLEC6A Antibody (3D1) - Azide Free [NBP2-36486] - Surface staining of Dectin-2 on 5x10^5 human PBMCs using 0.5 ug of Dectin-2 antibody (red) and 0.5 ug of isotype control antibody (green). Image ...read more

Product Details

Summary
Reactivity Hu, PmSpecies Glossary
Applications WB, Flow, IHC, IHC-P, CyTOF-ready
Clone
3D1
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Format
Azide Free
Concentration
1.0 mg/ml

Order Details

Dectin-2/CLEC6A Antibody (3D1) - Azide Free Summary

Immunogen
A portion of amino acids 75-139 of human Dectin-2 was used as the immunogen for the antibody. 90-106
Isotype
IgG3 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
CLEC6A
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Flow Cytometry 1ul/1 million cells
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 5 ug/ml
  • Western Blot 2-5 ug/ml

Reactivity Notes

Orangutan, chimp (100%), Rhesus monkey, Bovine, Sheep (83%), Mouse (65%), Rat (52%).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
No Preservative
Concentration
1.0 mg/ml
Purity
Protein G purified

Alternate Names for Dectin-2/CLEC6A Antibody (3D1) - Azide Free

  • CLEC4N
  • CLEC6A
  • CLECSF10
  • C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamilymember 10
  • C-type lectin domain family 6 member A
  • C-type lectin domain family 6, member A
  • C-type lectin superfamily member 10
  • DC-associated C-type lectin 2
  • dectin 2
  • Dectin2
  • Dectin-2
  • Dendritic cell-associated C-type lectin 2

Background

Dectin-2 is a C-type lectin expressed by dendritic cells, macrophages and inflammatory monocytes. It is a type II membrane receptor, with a short cytoplasmic tail, and a C-terminal C-type lectin domain. Dectin-2 is a receptor with specificity for high mannose structures and mediates cytokine production from DC and other antigen presenting cells. Though, Dectin-2 has no obvious signaling motifs attached to CP tail, reports indicate that Dectin-2 employs FcR 7; for internalization and to activate NF-kB pathway for cytokine production. Though it shares only 20-25% of homology with Dectin-1, it functions similarly as pattern recognition receptor (PRR) for fungal infections, to activate both innate (Syk-CARD9 innate signaling pathway) and adaptive immune responses (by activation of DC) to fungal infections. Thus Dectin-2 is a connector molecule of both innate and adaptive immunity functioning at DC level.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 NBP2-27159AF350
Alexa Fluor 405 NBP2-27159AF405
Alexa Fluor 488 NBP2-27159AF488
Alexa Fluor 532 NBP2-27159AF532
Alexa Fluor 594 NBP2-27159AF594
Alexa Fluor 647 NBP2-27159AF647
Alexa Fluor 700 NBP2-27159AF700
Alexa Fluor 750 NBP2-27159AF750
Allophycocyanin NBP2-27159APC
Biotin NBP2-27159B
DyLight 350 NBP2-27159UV
DyLight 405 NBP2-27159V
DyLight 488 NBP2-27159G
DyLight 550 NBP2-27159R
DyLight 594 NBP2-27159DL594
DyLight 650 NBP2-27159C
DyLight 680 NBP2-27159FR
DyLight 755 NBP2-27159IR
FITC NBP2-27159F
HRP NBP2-27159H
Janelia Fluor 549 NBP2-27159JF549
Janelia Fluor 549 NBP2-36486JF549
Janelia Fluor 646 NBP2-27159JF646
Janelia Fluor 646 NBP2-36486JF646
PE NBP2-27159PE
PerCP NBP2-27159PCP

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Bioinformatics

Gene Symbol CLEC6A