Decorin Antibody [Unconjugated]


Western blot shows lysates of human uterus tissue and human heart tissue. PVDF membrane was probed with 0.1 µg/mL of Goat Anti-Human Decorin Antigen Affinity-purified Polyclonal Antibody (Catalog # AF143) followed by more
Decorin was detected in immersion fixed paraffin-embedded sections of human breast using Goat Anti-Human Decorin Antigen Affinity-purified Polyclonal Antibody (Catalog # AF143) at 15 µg/mL overnight at 4 °C. Tissue more
Simple Western lane view shows lysates of human uterus and human heart tissue, loaded at 0.2 mg/mL. A specific band was detected for Decorin at approximately 140-149 kDa (as indicated) using 5 µg/mL of Goat more

Product Details

Reactivity HuSpecies Glossary
Applications WB, Simple Western, IHC

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Decorin Antibody [Unconjugated] Summary

S. frugiperda insect ovarian cell line Sf 21-derived recombinant human Decorin
Accession # P07585
Detects human Decorin in direct ELISAs and Western blots.
Purity Statement
Antigen Affinity-purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.


  • Immunohistochemistry 10-20 ug/mL
  • Simple Western 5 ug/mL
  • Western Blot 0.1 ug/mL
Read Publications using
AF143 in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
No Preservative
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Decorin Antibody [Unconjugated]

  • Bone proteoglycan II
  • CSCD
  • DCN
  • decorin proteoglycan
  • Decorin
  • dermatan sulphate proteoglycans II
  • DSPG2
  • PG40
  • PGII
  • PG-II
  • PGS2
  • PG-S2
  • proteoglycan core protein
  • SLRR1B
  • small leucine-rich protein 1B


Decorin is a small secreted chondroitin/dermatan sulfate proteoglycan in the family of small leucine-rich proteoglycans (SLRPs). SLRP family members are characterized by N-terminal and C-terminal cysteine-rich regions which flank the central region containing 10‑12 tandem leucine-rich repeats (LRR) (1, 2). The human Decorin cDNA encodes a 359 amino acid (aa) precursor that includes a 16 aa signal sequence and a 14 aa propeptide. The 329 aa mature protein contains twelve LRR. Alternate splicing generates five isoforms with variable length deletions (3). Mature human and mouse Decorin share 80% aa sequence identity. In Decorin, serine 34 in the N-terminal domain is O-glycosylated. Naturally occurring Decorin proteoglycan has a molecular mass of approximately 100 kDa, and the deglycosylated Decorin core protein has a mass of approximately 40 kDa. Decorin binds to fibronectin, TGF-beta , and type I and type II collagens. The binding of Decorin to various molecules was reported to be mediated via the core protein. Decorin has been implicated in matrix assembly and has also been reported to suppress the growth of various tumor cell lines by activating the epidermal growth factor receptor.

  1. Naito, Z. (2005) J. Nippon Med. Sch. 72:137.
  2. Matsushima, N. et al. (2005) Cell. Mol. Life Sci. 62:2771.
  3. Danielson, K. et al. (1993) Genomics 15:146.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Decorin Antibody (AF143)(20)

We have publications tested in 5 confirmed species: Human, Mouse, Rat, Bovine, Hamster.

We have publications tested in 9 applications: Co-IP, ELISA Development, Functional Assay, ICC, IHC, IHC-Fr, IHC-P, Neutralization, Western Blot.

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Showing Publications 1 - 10 of 20. Show All 20 Publications.
Publications using AF143 Applications Species
D Basak, Z Jamal, A Ghosh, PK Mondal, P Dey Talukd, S Ghosh, B Ghosh Roy, R Ghosh, A Halder, A Chowdhury, GK Dhali, BK Chattopadh, ML Saha, A Basu, S Roy, C Mukherjee, NK Biswas, U Chatterji, S Datta Reciprocal interplay between asporin and decorin: Implications in gastric cancer prognosis PLoS ONE, 2021-08-11;16(8):e0255915. 2021-08-11 [PMID: 34379688] (Co-IP, Western Blot, Human) Co-IP, Western Blot Human
CH Liu, BR Wu, YJ Ho, YH Chu, WC Hsu, TJ Tseng, JP Li, WC Liao CHPF Regulates the Aggressive Phenotypes of Hepatocellular Carcinoma Cells via the Modulation of the Decorin and TGF-&beta Pathways Cancers, 2021-03-12;13(6):. 2021-03-12 [PMID: 33809195] (ICC, Human) ICC Human
AF Asega, MC Menezes, D Trevisan-S, D Cajado-Car, L Bertholim, AK Oliveira, A Zelanis, SMT Serrano Cleavage of proteoglycans, plasma proteins and the platelet-derived growth factor receptor in the hemorrhagic process induced by snake venom metalloproteinases Sci Rep, 2020-07-31;10(1):12912. 2020-07-31 [PMID: 32737331] (Western Blot, Mouse) Western Blot Mouse
J Svärd, TH Røst, CEN Sommervoll, C Haugen, OA Gudbrandse, AE Mellgren, E Rødahl, J Fernø, SN Dankel, JV Sagen, G Mellgren Absence of the proteoglycan decorin reduces glucose tolerance in overfed male mice Sci Rep, 2019-03-15;9(1):4614. 2019-03-15 [PMID: 30874564] (Western Blot, Mouse) Western Blot Mouse
AD Kolb, AB Shupp, D Mukhopadhy, FC Marini, KM Bussard Osteoblasts are "educated" by crosstalk with metastatic breast cancer cells in the bone tumor microenvironment Breast Cancer Res., 2019-02-27;21(1):31. 2019-02-27 [PMID: 30813947] (Functional Assay, IHC-P, Human) Functional Assay, IHC-P Human
MB Goncalves, Y Wu, E Clarke, J Grist, C Hobbs, D Trigo, J Jack, JPT Corcoran Regulation of myelination by exosome associated retinoic acid release from NG2-positive cells J. Neurosci., 2019-02-13;0(0):. 2019-02-13 [PMID: 30760627] (IHC-P, Rat) IHC-P Rat
Menon R, Otto E, Kokoruda A, Zhou J, Zhang Z, Yoon E, Chen Y, Troyanskaya O, Spence J, Kretzler M, Cebrian C Single-cell analysis of progenitor cell dynamics and lineage specification in the human fetal kidney. Development, 2018-08-30;145(16):. 2018-08-30 [PMID: 30166318] (IHC, Human) IHC Human
AR Yoon, J Hong, CO Yun Adenovirus-mediated decorin expression induces cancer cell death through activation of p53 and mitochondrial apoptosis Oncotarget, 2017-09-08;8(44):76666-76685. 2017-09-08 [PMID: 29100340] (Western Blot, Human) Western Blot Human
Maternal obesity drives functional alterations in uterine NK cells JCI Insight, 2016-07-21;1(11):e85560. 2016-07-21 [PMID: 27699222] (Neutralization, Human) Neutralization Human
Glucosamine exposure reduces proteoglycan synthesis in primary human endothelial cells in vitro Food Nutr Res, 2016-09-23;60(0):32615. 2016-09-23 [PMID: 27667774] (Western Blot, Human) Western Blot Human
Show All 20 Publications.

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Gene Symbol DCN