DC8 Antibody [Janelia Fluor® 525]

• Reactivity: Hu
• Applications: WB, ICC/IF
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Janelia Fluor 525

DC8 Antibody [Janelia Fluor® 525] Summary

• Immunogen: Produced in rabbits immunized with a synthetic peptide corresponding to the center region of the Human DC8.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: NSL1
• Purity: Antigen and protein A Affinity-purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Antigen and protein A Affinity-purified

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for DC8 Antibody [Janelia Fluor® 525]

• C1orf48
• chromosome 1 open reading frame 48
• DC8
• DKFZp566O1646
• kinetochore-associated protein NSL1 homolog
• MIS14
• NSL1, MIND kinetochore complex component, homolog (S. cerevisiae)

Background

DC8 encodes a protein with two coiled-coil domains that localizes to kinetochores, which are chromosome-associated structures that attach to microtubules and mediate chromosome movements during cell division. It is part of a conserved protein complex that includes two chromodomain-containing proteins and a component of the outer plate of the kinetochore. This protein complex is proposed to bridge centromeric heterochromatin with the outer kinetochore structure. Multiple transcript variants encoding different isoforms have been found for this gene.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: NSL1