DC-SIGN/CD209 Antibody (UW60.1) - BSA Free

Flow Cytometry: DC-SIGN/CD209 Antibody (UW60.1) [NBP2-21791] - Staining of human monocytes-derived dendritic cells with anti-human CD209 (UW60.1) PE.

Flow Cytometry: DC-SIGN/CD209 Antibody (UW60.1) [NBP2-21791] - Surface staining of human monocytes-derived dendritic cells with anti-human CD209 (UW60.1) APC.

Product Discontinued

DC-SIGN/CD209 Antibody (UW60.1) - BSA Free Summary

• Immunogen: CD209-His-tagged fusion protein.
• Marker: Dendritic Cell Marker
• Specificity: The mouse monoclonal antibody UW60.1 recognizes human CD209 (DC-SIGN), a 44 kDa transmembrane receptor expressed on the surface of dendritic cells and macrophages.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: CD209
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • CyTOF-ready
  • Flow Cytometry 1-4 ug/ml
  • Immunocytochemistry/ Immunofluorescence 1:50-1:300
  • Immunohistochemistry 1:50-1:300
• Application Notes: This antibody is Cytof ready.
• Theoretical MW: 44 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: Phosphate buffered saline (PBS), pH 7.4
• Preservative: 15mM Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Protein A purified

Alternate Names for DC-SIGN/CD209 Antibody (UW60.1) - BSA Free

• CD209 antigendendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbingnon-integrin
• CD209 molecule
• CD209
• CDSIGNHIV gpl20-binding protein
• CLEC4L
• CLEC4LC-type lectin domain family 4 member L
• DCSIGN
• DC-SIGN
• DC-SIGN1
• DC-SIGN1C-type lectin domain family 4, member L
• DC-SIGNMGC129965
• Dendritic cell-specific ICAM-3-grabbing non-integrin 1

Background

CD209, also known as DC-SIGN (dendritic cell-specific ICAM-3-grabbing nonintegrin) is a transmembrane receptor expressed on the surface of dendritic cells and macrophages, which recognizes numerous pathogens ranging from parasites to viruses. Its N-terminal domain is transmembrane, whereas a tandem-repeat neck domain and the C terminal C-type lectin carbohydrate recognition domain have dual function as a pathogen recognition receptor and a cell adhesion receptor. The neck region is responsible for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. A ligand of CD209 is also CD50 (ICAM-3).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for DC-SIGN/CD209 Antibody (NBP2-21791)(1)

Publication using NBP2-21791

• Langenfurth A, Gu S, Bautze V et al. Decreased demand for olfactory periglomerular cells impacts on neural precursor cell viability in the rostral migratory stream. Sci Rep 2016-08-30 [PMID: 27573347] (IF/IHC)

Bioinformatics

• Gene Symbol: CD209
• Entrez:
  • 30835(Human)