Cytosolic Sulfotransferase 1A1/SULT1A1 Antibody (638708) [Alexa Fluor® 350]

• Applications: WB, IHC, IP
• Clone: 638708
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 350

Cytosolic Sulfotransferase 1A1/SULT1A1 Antibody (638708) [Alexa Fluor® 350] Summary

• Immunogen: E. coli-derived recombinant human Cytosolic Sulfotransferase 1A1/SULT1A1
  Glu2-Leu295
  Accession # P50225
• Specificity: Detects human Cytosolic Sulfotransferase 1A1/SULT1A1 in direct ELISAs and Western blots. In direct ELISAs, 100% cross-reactivity with recombinant human (rh) SULT1A3 and rhSULT1C4 and approximately 10% cross-reactivity with rhSULT1B1 is observed. No cross-
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

Cytosolic Sulfotransferase 1A1 (SULT1A1; also phenol sulfotransferase 1 and thermostable phenol sulfotransferase) is a 35 kDa enzyme belonging to the sulfotransferase 1 family of proteins.  Human SULT1A1 is 295 amino acids (aa) in length.  Human SULT1A1 shares 78% and 73% aa identity with rat and mouse SULT1A1, respectively.  SULT1A1 exists as a homodimer and is expressed in liver, lung, adrenal gland, brain, platelets, and skin.  Functionally, it catalyzes the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitter.  It also mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could participate as a modulating factor of cancer risk.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.