Cytosolic beta-Glucosidase/GBA3 Antibody (728702) [Alexa Fluor® 594]

• Reactivity: Hu
• Applications: ICC/IF
• Clone: 728702
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 594

Cytosolic beta-Glucosidase/GBA3 Antibody (728702) [Alexa Fluor® 594] Summary

• Immunogen: S. frugiperda insect ovarian cell line Sf 21-derived recombinant human Cytosolic β‑Glucosidase/GBA3
  Thr13-Leu469
  Accession # Q9H227
• Specificity: Detects human Cytosolic beta ‑Glucosidase/GBA3 in direct ELISAs.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Cytosolic beta-Glucosidase/GBA3 Antibody (728702) [Alexa Fluor® 594]

• CBG
• CBGL1
• CBGL1GLUC
• Cytosolic betaGlucosidase
• Cytosolic beta-Glucosidase
• Cytosolic beta-glucosidase-like protein 1
• EC 3.2.1.21
• GBA3
• GLUC
• glucosidase, beta, acid 3 (cytosolic)
• klotho-related protein
• KLrP
• MGC104276
• MGC126878

Background

There are three beta-glucosidases (GBA) in human genome. GBA1 endodes a lysosomal membrane protein that cleaves the beta-glucosidic linkage of glucosylceramide (1). GBA2 encodes a microsomal beta-glucosidase that catalyzes the hydrolysis of bile acid 3-O-glucosides (2). GBA3 is a cytosolic beta-glucosidase and is predominantly expressed in liver. GBA3 efficiently hydrolyzes beta-D-glucoside and beta-D-galactoside, but not any known physiological beta-glycoside, suggesting that it may be involved in detoxification of plant glycosides (3). GBA3 also has significant neutral glycosylceramidase activity, suggesting that it may be involved in a nonlysosomal catabolic pathway of glucosylceramide metabolism (4). At the protein level, GBA3 shows significant homology (>40%) with Klotho protein that is known for its association with aging process (3, 4).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.