Cytosolic beta-Glucosidase/GBA3 Antibody (728702) [Alexa Fluor™ Plus 405]

• Reactivity: Hu
• Clone: 728702
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 405

Cytosolic beta-Glucosidase/GBA3 Antibody (728702) [Alexa Fluor™ Plus 405] Summary

• Specificity: Detects human Cytosolic beta ‑Glucosidase/GBA3 in direct ELISAs.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Cytosolic beta-Glucosidase/GBA3 Antibody (728702) [Alexa Fluor™ Plus 405]

• CBG
• CBGL1
• CBGL1GLUC
• Cytosolic betaGlucosidase
• Cytosolic beta-Glucosidase
• Cytosolic beta-glucosidase-like protein 1
• EC 3.2.1.21
• GBA3
• GLUC
• glucosidase, beta, acid 3 (cytosolic)
• klotho-related protein
• KLrP
• MGC104276
• MGC126878

Background

There are three beta-glucosidases (GBA) in human genome. GBA1 endodes a lysosomal membrane protein that cleaves the beta-glucosidic linkage of glucosylceramide (1). GBA2 encodes a microsomal beta-glucosidase that catalyzes the hydrolysis of bile acid 3-O-glucosides (2). GBA3 is a cytosolic beta-glucosidase and is predominantly expressed in liver. GBA3 efficiently hydrolyzes beta-D-glucoside and beta-D-galactoside, but not any known physiological beta-glycoside, suggesting that it may be involved in detoxification of plant glycosides (3). GBA3 also has significant neutral glycosylceramidase activity, suggesting that it may be involved in a nonlysosomal catabolic pathway of glucosylceramide metabolism (4). At the protein level, GBA3 shows significant homology (>40%) with Klotho protein that is known for its association with aging process (3, 4).

1. Tybulewicz, V.L. et al. (1992) Nature 357:407.
2. Matern, H. et al. (2001) J. Biol. Chem. 276:37929.
3. de Graaf, M. et al. (2001) Biochem. J. 356:907.
4. Hayashi, Y. et al. (2007) J. Biol. Chem. 282:30889.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.