Cystatin A Antibody (224705) [Alexa Fluor™ Plus 647]

• Reactivity: Hu
• Clone: 224705
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 647

Cystatin A Antibody (224705) [Alexa Fluor™ Plus 647] Summary

• Specificity: Detects human Cystatin A in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant human (rh) Cystatins B, C, D, E/M, F, S, SA, rhFetuin A, rhFetuin B, rhHPRG, rhKininogen, or rhKininostatin is observed.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Cystatin A Antibody (224705) [Alexa Fluor™ Plus 647]

• AREI
• CSTA
• cystatin A (stefin A)
• Cystatin A
• cystatin AS
• cystatin-A
• Stefin A
• STF1
• STF1Cystatin-AS
• STFA
• STFAStefin-A

Background

Cystatin A, also called stefin A, Cystatin AS or keratolinin, is a member of family 1 of the cystatin superfamily (1, 2). Like Cystatin B, it is an intracellular inhibitor regulating the activities of cysteine proteases of the papain family such as cathepsins B, H and L (3). For example, immunohistochemical analysis of Cystatin A and cathepsin L is a useful indicator for malignancy in human epidermal keratinocytes (4). The ratio of cathepsin B and Cystatin A can be used in the differential diagnosis and treatment of patients with prostate carcinoma (5). The human Cystatin A consists of 98 amino acids (1).

1. Kartasova, T. et al. (1987) Nucleic Acids Res. 15:5945.
2. Abrahamson, M. (1994) Methods Enzymol. 244:685.
3. Jenko, S. et al. (2003) J. Mol. Biol. 326:875.
4. Palungwachira, P. et al. (2002) J. Dermatol. 29:573.
5. Sinha, A.A. et al. (2002) Cancer 94:3141.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.