CXCR3 Antibody (868013) [Phycoerythrin]

Rat splenocytes were stained with anti-rat CD4 APC-conjugated antibody and either (A) Mouse Anti-Rat CXCR3 PE-conjugated Monoclonal Antibody (Catalog # FAB8109P) or (B) Mouse IgG2BPhycoerythrin Isotype Control (Catalog # IC0041P). View our protocol for Staining Membrane-associated Proteins.

• Reactivity: Rt
• Applications: Flow
• Clone: 868013
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Phycoerythrin

CXCR3 Antibody (868013) [Phycoerythrin] Summary

• Immunogen: NS0 mouse myeloma cell line transfected with rat CXCR3
  Accession # Q9J119
• Specificity: Detects rat CXCR3 in direct ELISAs. Stains rat CXCR3 transfected cells but not irrelevant transfectants.
• Source: N/A
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: CXCR3
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 10 uL/10^6 cells

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
• Buffer: Supplied in a saline solution containing BSA and Sodium Azide.
• Preservative: Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CXCR3 Antibody (868013) [Phycoerythrin]

• CD183 antigen
• CD183
• chemokine (C-X-C motif) receptor 3
• chemokine (C-X-C) receptor 3
• CKR-L2IP-10 receptor
• CMKAR3
• C-X-C chemokine receptor type 3
• CXCR3
• CXC-R3
• CXCR-3
• G protein-coupled receptor 9CD182
• GPR9
• GPR9Mig-R
• Interferon-inducible protein 10 receptor
• IP10 receptor
• IP10-R
• Mig receptor
• MigR

Background

CXCR3, also known as CD183, is an approximately 41 kDa (predicted) 7-transmembrane spanning receptor for the chemokines CXCL9, CXCL10, and CXCL11. It is expressed on activated T cells, B cells, and NK cells during inflammation. It is additionally upregulated on solid tumor cells, tumor endothelium, and cancer stem cells. CXCR3 plays a role in leukocyte recruitment to sites of inflammation. It also contributes to Th1 biased responses during autoimune diseases rheumatoid arthritis, systemic erythematosis, and type 1 diabetes. Rat CXCR3 shares 86% and 96% amino acid sequence identity with human and mouse CXCR3, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for CXCR3 Antibody (FAB8109P)(2)

Publications using FAB8109P

• Hua Xu, Ai-ling Yu, Da-peng Zhao, Guang-yuan Meng, Ling Wang, Min Shan et al. Ursolic acid inhibits Th17 cell differentiation via STAT3/ROR gamma t pathway and suppresses Schwann cell-mediated Th17 cell migration by reducing CXCL9/10 expression Innate Immunity 7/1/2022 [PMID: 35548957]
• B Dou, W Zhou, S Li, L Wang, X Wu, Y Li, H Guan, C Wang, S Zhu, Z Ke, C Huang, Z Wang Buyang Huanwu Decoction Attenuates Infiltration of Natural Killer Cells and Protects Against Ischemic Brain Injury Cell. Physiol. Biochem., 2018-10-24;50(4):1286-1300. 2018-10-24 [PMID: 30355926] (Flow Cytometry, Rat)

Bioinformatics

• Gene Symbol: CXCR3
• Uniprot:
  • Q9J119()