CXCL2/GRO beta/MIP-2/CINC-3 Antibody [Biotin] Summary
E. coli-derived recombinant mouse CXCL2/MIP-2 (R&D Systems, Catalog # 452-M2)
Accession # P10889
Detects mouse CXCL2/MIP-2 in ELISAs and Western blots. In sandwich immunoassays, less than 0.05% cross-reactivity with recombinant human (rh) GRO beta, rhGRO gamma, recombinant mouse (rm) C10, rmMIP-1 alpha, rmMIP-1 beta, rhRANTES, and rmKC is observed.
Test in a species/application not listed above to receive a full credit towards a future purchase.
- Western Blot 0.1 ug/mL
- Immunohistochemistry 5-15 ug/mL
- ELISA Capture (Matched Antibody Pair) 2-8 ug/mL
- ELISA Detection (Matched Antibody Pair) 0.1-0.4 ug/mL
- Immunocytochemistry 5-15 ug/mL
- ELISA Standard (Matched Pair)
ELISA Capture: Mouse CXCL2/GRO beta/MIP-2/CINC-3 Antibody (Catalog # MAB452)
ELISA Detection: Mouse CXCL2/GRO beta/MIP-2/CINC-3 Biotinylated Antibody (Catalog # BAF452)
Standard: Recombinant Mouse CXCL2/MIP-2 (Catalog # 452-M2)
Packaging, Storage & Formulations
|Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Reconstitute at 0.2 mg/mL in sterile PBS.
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for CXCL2/GRO beta/MIP-2/CINC-3 Antibody [Biotin]
- chemokine (C-X-C motif) ligand 2
- C-X-C Motif Chemokine 2
- GRO beta
- GRO2 oncogene
- Growth-regulated protein beta
- Macrophage inflammatory protein 2-alpha
- melanoma growth stimulatory activity beta
- MGSA beta
Macrophage Inflammatory Protein-2 (MIP-2) was originally identified as a heparin-binding protein secreted from a murine macrophage cell line in response to endotoxin stimulation. Based on its protein and DNA sequences, MIP-2 is a member of the alpha (C-X-C) subfamily of chemokines.
MIP-2 cDNA encodes a 100 amino acid residue precursor protein from which the amino-terminal 27 amino acid residues are cleaved to generate the mature MIP-2. The protein sequence of murine MIP-2 shows approximately 63% identity to that of murine KC, another murine alpha chemokine whose expression is induced by PDGF. In addition, the protein sequence of MIP-2 is also 60% identical to human GRO beta and GRO gamma. It has been suggested that mouse KC and MIP-2 are the homologs of the human GROs and rat CINCs.
Similarly to other alpha chemokines, murine MIP-2 is a potent neutrophil attractant and activator. MIP-2 and KC can bind the murine interleukin 8 type B receptor homologue with high affinity. The expression of MIP-2 was found to be associated with neutrophil influx in pulmonary inflammation and glomerulonephritis, suggesting that MIP-2 may contribute to the pathogenesis of inflammatory diseases.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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