CtIP Antibody (19E8)

Images

 
Immunocytochemistry/ Immunofluorescence: CtIP Antibody (19E8) [NBP1-41205] - Analysis of paraformaldehyde-fixed HeLa, using antibody at 1:100 dilution.

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, ChIP, ICC/IF, IP
Clone
19E8
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
1.3 mg/ml

CtIP Antibody (19E8) Summary

Immunogen
Human CtIP
Specificity
This antibody will recognize human CtIP.
Isotype
IgG
Clonality
Monoclonal
Host
Mouse
Gene
RBBP8
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
  • Chromatin Immunoprecipitation
  • Immunocytochemistry/Immunofluorescence 1:10 - 1:500
  • Immunoprecipitation
Application Notes
ChIP and IP usages reported in scientific literature.
Theoretical MW
125 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Publications
Read Publications using
NBP1-41205 in the following applications:

  • 3 publications
  • IP
    3 publications
  • WB
    3 publications

Reactivity Notes

Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Additional Mouse on Mouse blocking steps may be required for IHC and ICC experiments. Please contact Technical Support for more information.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.4)
Preservative
No Preservative
Concentration
1.3 mg/ml
Purity
Immunogen affinity purified

Alternate Names for CtIP Antibody (19E8)

  • CtBP-interacting protein
  • CtIP
  • DNA endonuclease RBBP8
  • EC 3.1
  • RBBP-8
  • retinoblastoma binding protein 8
  • Retinoblastoma-binding protein 8
  • Retinoblastoma-interacting protein and myosin-like
  • RIMSAE2
  • Sporulation in the absence of SPO11 protein 2 homolog

Background

CtIP, a 125 kD protein, was originally found interacting with a transcription repressor, CtBP, through the PLDLS motif (CtBP-Interacting Protein) thus suggested a role in transcription. Studies have shown that CtIP also interacts with BRCA1 protein through the c-terminus BRCT domains also suggested that CtIP is a potential tumor suppressor. This CtIP-BRCA1 interaction can be disruppted by DNA damaging agents including UV or gamma-irradiation. Li et al (Nature 406, 210 - 215 (2000)) have shown that ATM phosphorylates CtIP at serine residues 664 and 745, and mutation of these sites abrogates the dissociation of BRCA1 from CtIP, resulting in persistent repression of BRCA1-dependent induction of GADD45 upon ionizing radiation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for CtIP Antibody (NBP1-41205)(3)

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 3 applications: ChIP, IP, WB.


Filter By Application
ChIP
(3)
IP
(3)
WB
(3)
All Applications
Filter By Species
Human
(3)
Mouse
(3)
All Species

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ChIP Video Protocol
ChIP Webinar
ICC/IF Video Protocol

FAQs for CtIP Antibody (NBP1-41205) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 405 Labeled NBP1-41205AF405
Alexa Fluor 488 Labeled NBP1-41205AF488
Alexa Fluor 647 Labeled NBP1-41205AF647
Alexa Fluor 700 Labeled NBP1-41205AF700
DyLight 350 Labeled NBP1-41205UV
DyLight 405 Labeled NBP1-41205V
DyLight 488 Labeled NBP1-41205G
DyLight 680 Labeled NBP1-41205FR
DyLight 755 Labeled NBP1-41205IR

Additional CtIP Products

CtIP NBP1-41205

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Bioinformatics

Gene Symbol RBBP8
Entrez