CRM1 Antibody

Product Discontinued

CRM1 Antibody Summary

• Immunogen: Recombinant protein encompassing a sequence within the N-terminus region of human CRM1. The exact sequence is proprietary.
• Localization: Cytoplasm; Nucleus; nucleoplasm; Cajal body; nucleolus
• Predicted Species: Mouse (99%), Rat (99%), Chicken (99%), Xenopus (96%), Rhesus Macaque (100%), Bovine (99%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: XPO1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 1:100-1:1000
  • Immunohistochemistry 1:100-1:1000
  • Immunohistochemistry-Paraffin 1:100-1:1000
  • Western Blot 1:500-1:3000
• Theoretical MW: 123 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Xenopus laevis (96%).

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7), 20% Glycerol, 1% BSA
• Preservative: 0.01% Thimerosal
• Purity: Immunogen affinity purified

Alternate Names for CRM1 Antibody

• Chromosome region maintenance 1 protein homolog
• DKFZp686B1823
• emb
• Exp1
• exportin 1 (CRM1 homolog, yeast)
• exportin 1 (CRM1, yeast, homolog)
• Exportin-1 (required for chromosome region maintenance)
• exportin-1
• yeast, homolog

Background

The protein encoded by this gene mediates leucine-rich nuclear export signal (NES)-dependent protein transport. Exportin 1 specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects.  For more information go to www.P65Warnings.ca.gov.

Publications for CRM1 Antibody (NBP2-16014)(1)

Publication using NBP2-16014

• Steyaert J, Scheveneels W, Vanneste J et al. FUS-Induced neurotoxicity in drosophila is prevented by downregulating nucleocytoplasmic transport proteins Human Molecular Genetics 2018-08-24 [PMID: 30379317] (IF/IHC, Human)

Bioinformatics

• Gene Symbol: XPO1
• Uniprot:
  • O14980(Human)