CRM1 Antibody

Images

 
Western Blot: CRM1 Antibody [NBP2-16014] - Sample (30 ug of whole cell lysate) A: HeLa 5% SDS PAGE gel, diluted at 1:500.
Immunocytochemistry/ Immunofluorescence: CRM1 Antibody [NBP2-16014] - Analysis of paraformaldehyde-fixed HeLa, using antibody at 1:500 dilution.
Immunohistochemistry-Paraffin: CRM1 Antibody [NBP2-16014] - Immunohistochemical analysis of paraffin-embedded Colon ca, using antibody at 1:250 dilution.

Product Details

Summary
Reactivity Hu, Mu, Rt, Bv, Ch, RM, XpSpecies Glossary
Applications WB, ICC/IF, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

CRM1 Antibody Summary

Immunogen
Recombinant protein encompassing a sequence within the N-terminus region of human CRM1. The exact sequence is proprietary.
Localization
Cytoplasm; Nucleus; nucleoplasm; Cajal body; nucleolus
Predicted Species
Mouse (99%), Rat (99%), Chicken (99%), Xenopus (96%), Rhesus Macaque (100%), Bovine (99%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
XPO1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:3000
  • Immunocytochemistry/Immunofluorescence 1:100-1:1000
  • Immunohistochemistry 1:100-1:1000
  • Immunohistochemistry-Paraffin 1:100-1:1000
Theoretical MW
123 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Xenopus laevis (96%).

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.0), 1.0% BSA and 20% Glycerol
Preservative
0.01% Thimerosal
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for CRM1 Antibody

  • Chromosome region maintenance 1 protein homolog
  • DKFZp686B1823
  • emb
  • exp1
  • exportin 1 (CRM1 homolog, yeast)
  • exportin 1 (CRM1, yeast, homolog)
  • Exportin-1 (required for chromosome region maintenance)
  • exportin-1
  • yeast, homolog

Background

The protein encoded by this gene mediates leucine-rich nuclear export signal (NES)-dependent protein transport. Exportin 1 specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for CRM1 Antibody (NBP2-16014) (0)

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Secondary Antibodies

 

Isotype Controls

Additional CRM1 Products

Bioinformatics Tool for CRM1 Antibody (NBP2-16014)

Discover related pathways, diseases and genes to CRM1 Antibody (NBP2-16014). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for CRM1 Antibody (NBP2-16014)

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Research Areas for CRM1 Antibody (NBP2-16014)

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Blogs on CRM1.

Survivin Acetylation: Affecting Apoptosis and Cancer
Survivin (BRIC5) is an inhibitor of apoptosis that also promotes cellular adaptation under stressful conditions and helps to regulate cell division. Recently, an antibody study by Dr. H Wang et al. at Brown University [PMID: 20826784] found that Survi...  Read full blog post.

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Bioinformatics

Gene Symbol XPO1
Uniprot