Coagulation Factor XIV/Protein C Antibody (PC 7) - BSA Free

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Immunohistochemistry: Coagulation Factor XIV/Protein C Antibody (PC 7) - BSA Free [NBP1-05113] - Human fallopian tube stained with Coagulation Factor XIV/Protein C Antibody.

Product Details

Summary
Reactivity Hu, NASpecies Glossary
Applications ELISA, IHC
Clone
PC 7
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Format
BSA Free
Concentration
1.0 mg/ml

Coagulation Factor XIV/Protein C Antibody (PC 7) - BSA Free Summary

Immunogen
Recombinant form of human activated protein C (Drotrecogin alfa, Xigris)
Specificity
Has specificity for a conformation dependent neoepitope that is expressed in activated protein C upon complex-formation with alpha1-antitrypsin. No reaction is seen to non-complexed alpha1-antitrypsin and only very little cross reaction to protein C zymogen. Note that specificity is calcium dependent.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
PROC
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • ELISA 1:500
  • Immunohistochemistry 1:10-1:500

Reactivity Notes

Chemical

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
10mM Phosphate (pH 7.4) and 0.5M NaCl
Preservative
15mM Sodium Azide
Concentration
1.0 mg/ml
Purity
Protein A or G purified

Alternate Names for Coagulation Factor XIV/Protein C Antibody (PC 7) - BSA Free

  • Anticoagulant protein C
  • APC
  • Autoprothrombin IIA
  • Blood coagulation factor XIV
  • Coagulation Factor XIV
  • EC 3.4.21
  • EC 3.4.21.69
  • PC
  • PROC
  • PROC1
  • protein C (inactivator of coagulation factors Va and VIIIa)
  • Protein C
  • vitamin K-dependent protein C

Background

Protein C is a vitamin K-dependent serine protease produced in the liver and made up of 2 polypeptide chains. The 62kDa proenzyme is activated by thrombin and the active enzyme cleaves factor Va and VIIIa and thus inhibits blood coagulation. The molecular weight of the active enzyme is 55kDa and the normal concentrations in human plasma is approximately 1-3 ng/ml because of the very fast turnover, the proenzyme concentration is approximately 3 ug/ml. The activated protein C (APC) is inhibited by members of the serine protease inhibitor (serpin) family, og which alpha1-antitrypsin (AAT) and protein C inhibitor (PCI) are the most important.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol PROC
Entrez