Claudin-19 Antibody (693202) [Janelia Fluor® 549]

• Reactivity: Hu
• Applications: IHC
• Clone: 693202
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Janelia Fluor 549

Claudin-19 Antibody (693202) [Janelia Fluor® 549] Summary

• Immunogen: NS0 mouse myeloma cell line transfected with human Claudin-19
  Accession # Q8N6F1
• Specificity: Detects human Claudin-19 in direct ELISAs.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: CLDN19
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for Claudin-19 Antibody (693202) [Janelia Fluor® 549]

• claudin 19
• Claudin19
• Claudin-19
• CLDN19

Background

The product of this gene belongs to the claudin family. It plays a major role in tight junction-specific obliterationof the intercellular space, through calcium-independent cell-adhesion activity. Defects in this gene are the cause ofhypomagnesemia renal with ocular involvement (HOMGO). HOMGO is a progressive renal disease characterized by primaryrenal magnesium wasting with hypomagnesemia, hypercalciuria and nephrocalcinosis associated with severe ocularabnormalities such as bilateral chorioretinal scars, macular colobomata, significant myopia and nystagmus. Twotranscript variants encoding distinct isoforms have been identified for this gene. (provided by RefSeq)

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CLDN19