TRPM6 Antibody (RB3407)

• Reactivity: Hu
• Applications: WB, IHC
• Clone: RB3407
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Concentration: 1 mg/ml

TRPM6 Antibody (RB3407) Summary

• Immunogen: This TRPM6 (CHAK2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 317-348 amino acids from the Central region of human TRPM6 (CHAK2).(Accession#:NP_001170781.1;NP_001170782.1;NP_060132.3)
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: TRPM6
• Purity: Antigen and protein A Affinity-purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry-Paraffin
  • Western Blot

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.09% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Antigen and protein A Affinity-purified

Alternate Names for TRPM6 Antibody (RB3407)

• CHAK2HMGX
• Channel kinase 2
• EC 2.7.11.1
• FLJ22628
• HOMG
• HOMG1
• HSH
• hypomagnesemia, secondary hypocalcemia
• Melastatin-related TRP cation channel 6
• transient receptor potential cation channel subfamily M member 6
• transient receptor potential cation channel, subfamily M, member 6

Background

FUNCTION: Essential ion channel and serine/threonine-protein kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Isoforms of the type M6-kinase lack the ion channel region. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. SUBUNIT: Forms heterodimers with TRPM7. TRPM6 requires the presence of TRPM7 to be targeted to the cell membrane (in HEK 293 cells).; SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.; TISSUE SPECIFICITY: Highly expressed in kidney and colon. Isoform TRPM6a and isoform TRPM6b, are coexpressed with TRPM7 in kidney, and testis, and are also found in several cell lines of lung origin. Isoform TRPM6c is detected only in testis and in H510 small cell lung carcinoma cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TRPM6