Claudin-19 Antibody (693202) [Alexa Fluor® 488]

• Reactivity: Hu
• Applications: IHC
• Clone: 693202
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 488

Claudin-19 Antibody (693202) [Alexa Fluor® 488] Summary

• Immunogen: NS0 mouse myeloma cell line transfected with human Claudin-19
  Accession # Q8N6F1
• Specificity: Detects human Claudin-19 in direct ELISAs.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Claudin-19 Antibody (693202) [Alexa Fluor® 488]

• claudin 19
• Claudin19
• Claudin-19
• CLDN19

Background

Claudin-19 is a 23 kDa multipass membrane protein in the Claudin family of epithelial tight junction proteins. Claudin-19 is expressed by renal tubular epithelial cells, retinal pigment epithelial cells, and Schwann cells. It interacts with Claudin-16 to form cation-selective paracellular channels in the thick ascending loop of the kidney. Mutations of Claudin-19 are associated with renal disorders of magnesium and calcium reabsorption. Human Claudin-19 shares 95% aa sequence identity with mouse and rat Claudin-19. An alternate splice form of human Claudin-19 has a deletion within the C-terminal cytoplasmic region.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.