Cerebellin-1/Precerebellin Antibody

Images

 
Western Blot: Cerebellin-1/Precerebellin Antibody [NBP1-77239] - Mouse cerebellum lysate with precerebellin antibody at (A) 2 and (B) 4 ug/ml.
Immunohistochemistry-Paraffin: Cerebellin-1/Precerebellin Antibody [NBP1-77239] - Rat brain tissue using precerebellin antibody at 2 ug/ml.

Product Details

Summary
Reactivity Hu, Mu, Rt, BvSpecies Glossary
Applications WB, ELISA, IHC, IHC-P, IF
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

Cerebellin-1/Precerebellin Antibody Summary

Immunogen
Antibody was raised against a 15 amino acid synthetic peptide from the middle of human precerebellin. The immunogen is located within amino acids 50 - 100 of Precerebellin.
Predicted Species
Bovine (100%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
CBLN1
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 4 ug/ml
  • ELISA 1:100-1:2000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
  • Immunofluorescence
Application Notes
Precerebellin antibody can be used for the detection of precerebellin by Western blot at 2 - 4 mg/ml.
Control Peptide
Cerebellin-1/Precerebellin Peptide (NBP1-77239PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Cerebellin-1/Precerebellin Antibody

  • CBLN1
  • cerebellin 1 precursor
  • Cerebellin1
  • Cerebellin-1
  • CLN1
  • Precerebellin

Background

Precerebellin is the precursor of the brain-specific hexadecapeptide cerebellin, a protein with substantial similarity to the globular region of the B chain of complement component C1q. Cerebellin exerts neuromodulatory functions by directly stimulating norepinephrine release via the adenylate cyclase/pka- dependent signaling pathway; and indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release. The active form of precerebellin is highly enriched in postsynaptic structures of cerebellar Purkinje cells in cartwheel neurons of the dorsal cochlear nucleus. Because precerebellin belongs to the C1q/tumor necrosis factor superfamily of secreted proteins and has similarity to adiponectin and CTRP3, it has been suggested that precerebellin posseses functions other than those already stated.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol CBLN1
Entrez
Uniprot