CDP/CUTL1 Antibody [Alexa Fluor® 750]

• Reactivity: Hu
• Applications: WB
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Alexa Fluor 750

CDP/CUTL1 Antibody [Alexa Fluor® 750] Summary

• Immunogen: E. coli-derived recombinant human CDP/CUTL1
  Ile64-Ser268
  Accession # P39880
• Specificity: Detects human CDP/CUTL1 in direct ELISAs and Western blots.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CDP/CUTL1 Antibody [Alexa Fluor® 750]

• CASP
• CCAAT displacement protein
• CDP
• CDP/Cux
• CDPCCAAT displacement protein
• COY1
• cut (Drosophila)-like 1 (CCAAT displacement protein)
• CUT
• CUTL1
• cut-like 1, CCAAT displacement protein (Drosophila)
• cut-like homeobox 1
• CUX
• CUX1
• FLJ31745
• golgi integral membrane protein 6
• GOLIM6
• homeobox protein cut-like 1
• Homeobox protein cux-1
• Nbla10317
• p100
• p110
• p200
• p75
• protein CASP
• putative protein product of Nbla10317

Background

CDP (CCAAT Displacement Protein; also CUX-1 and CUTL-1) is a 180-190 kDa member of the CUT homeobox family of proteins. It is found in multiple cell types, and appears to act as a negative regulator of transcription for genes as diverse as c-myc, CD8 and TGF-beta RII. Repression is assumed to occur either by direct DNA interaction, which interferes with transcriptional activator binding to gene promoters, or through the recruitment of active HDACs to target gene promoter sequences. Human CDP is 1505 amino acids (aa) in length. It contains three consecutive DNA-binding CUT domains (aa 542-629; 934-1007; 1125-1202) plus one C-terminal homeobox domain (aa 1244-1303). CDP undergoes phosphorylation, resulting in its inactivation, and reportedly also homodimerizes. There are multiple splice variants (termed CASP), ranging from 75-85 kDa in size. Most are characterized by the presence of a unique 260 aa substitution for aa 410-1505 that contains a Golgi transmembrane domain. CDP also undergoes extensive proteolytic processing, creating functional DNA binding C-terminal fragments that range from 75-110 kDa in size. Over aa 64-268, human CDP shares 97% aa identity with mouse CDP.

                       

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.