CDIP Antibody

Images

 
Western Blot: CDIP Antibody [NBP1-76996] - Human brain lysate with CDIP antibody at (A) 0.25 and (B) 0.5 ug/ml.
Immunocytochemistry/ Immunofluorescence: CDIP Antibody [NBP1-76996] - Immunofluorescence of CDIP1 in mouse brain tissue with CDIP1 antibody at 20 ug/mL.
Immunohistochemistry-Paraffin: CDIP Antibody [NBP1-76996] - Mouse brain tissue with CDIP antibody at 2.5 ug/mL.

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, ELISA, ICC/IF, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

CDIP Antibody Summary

Immunogen
Antibody was raised against a 19 amino acid synthetic peptide near the center of human CDIP. The immunogen is located within amino acids 70 - 120 of CDIP.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
CDIP1
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • ELISA 1:100-1:2000
  • Immunocytochemistry/Immunofluorescence 20 ug/ml
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
Control Peptide
CDIP Peptide (NBP1-76996PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for CDIP Antibody

  • CDIP
  • cell death inducing protein
  • Cell death-inducing protein
  • chromosome 16 open reading frame 5
  • I1
  • LITAF-like protein
  • Transmembrane protein I1

Background

The p53 tumor-suppressor gene integrates numerous signals that control cell life and death; loss of its functions contributes to the development of most cancers. CDIP is a novel pro-apoptotic target gene whose inhibition abrogates p53-mediated apoptotic responses. Overexpression of CDIP induced apoptosis in transfected cells while siRNA suppression of caspase-8 mRNA blocked this CDIP-induced apoptosis, indicating that the CDIP-dependent apoptosis pathway proceeds through extrinsic cell death pathway. CDIP may thus represent a novel target for drug design to maximize p53 response and sensitize tumor cells to cancer therapy. Multiple isoforms of CDIP are known to exist.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

Additional CDIP Products

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Bioinformatics

Gene Symbol CDIP1
Uniprot