CDIP Antibody - BSA Free

Western Blot: CDIP Antibody [NBP1-76996] - Human brain lysate with CDIP antibody at (A) 0.25 and (B) 0.5 ug/ml.

Immunocytochemistry/ Immunofluorescence: CDIP Antibody - BSA Free [NBP1-76996] - Immunofluorescence of CDIP1 in mouse brain tissue with CDIP1 antibody at 20 ug/mL.

Immunohistochemistry: CDIP Antibody - BSA Free [NBP1-76996] - Immunohistochemistry of CDIP in mouse brain tissue with CDIP antibody at 2.5 ug/mL.

• Reactivity: Hu, Mu, Rt, Bv
• Applications: WB, ELISA, ICC/IF, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1 mg/ml

CDIP Antibody - BSA Free Summary

• Description: Novus Biologicals Rabbit CDIP Antibody - BSA Free (NBP1-76996) is a polyclonal antibody validated for use in IHC, WB, ELISA and ICC/IF. Anti-CDIP Antibody: Cited in 1 publication. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: Antibody was raised against a 19 amino acid synthetic peptide near the center of human CDIP. The immunogen is located within amino acids 70 - 120 of CDIP. Amino Acid Squence: YPPPGPHPPMGYYPPGPYT
• Predicted Species: Bovine (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: CDIP1
• Purity: Peptide affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Immunocytochemistry/ Immunofluorescence 20 ug/ml
  • Immunohistochemistry 2.5 ug/mL
  • Immunohistochemistry-Paraffin 2.5 ug/mL
  • Western Blot 0.25 - 0.5 ug/mL
• Control Peptide:

  CDIP Peptide (NBP1-76996PEP)

Reactivity Notes

Use in Rat reported in scientific literature (PMID:33391474)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Peptide affinity purified

Alternate Names for CDIP Antibody - BSA Free

• CDIP
• cell death inducing protein
• Cell death-inducing protein
• chromosome 16 open reading frame 5
• I1
• LITAF-like protein
• Transmembrane protein I1

Background

The p53 tumor-suppressor gene integrates numerous signals that control cell life and death; loss of its functions contributes to the development of most cancers. CDIP is a novel pro-apoptotic target gene whose inhibition abrogates p53-mediated apoptotic responses. Overexpression of CDIP induced apoptosis in transfected cells while siRNA suppression of caspase-8 mRNA blocked this CDIP-induced apoptosis, indicating that the CDIP-dependent apoptosis pathway proceeds through extrinsic cell death pathway. CDIP may thus represent a novel target for drug design to maximize p53 response and sensitize tumor cells to cancer therapy. Multiple isoforms of CDIP are known to exist.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for CDIP Antibody (NBP1-76996)(1)

Publication using NBP1-76996

• Liao Z, Chen Y, Duan C, et al. Cardiac telocytes inhibit cardiac microvascular endothelial cell apoptosis through exosomal miRNA-21-5p-targeted cdip1 silencing to improve angiogenesis following myocardial infarction Theranostics 2021-01-01 [PMID: 33391474] (WB, Rat)

Bioinformatics

• Gene Symbol: CDIP1
• Uniprot:
  • NP_037531(Human)