CD96 Antibody (NK92.39)

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, Func
Clone
NK92.39
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

CD96 Antibody (NK92.39) Summary

Immunogen
The immunogen for this antibody is proprietary information.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
CD96
Purity
Protein A or G purified
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Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 1:10-1:1000
  • Functional

Reactivity Notes

Human

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
0.2 um filtered solution in PBS and 0.1% BSA
Preservative
No Preservative
Purity
Protein A or G purified

Alternate Names for CD96 Antibody (NK92.39)

  • CD96 antigenMGC22596
  • CD96 molecule
  • CD96
  • DKFZp667E2122
  • T cell-activated increased late expression protein
  • TACTILE
  • TACTILEincreased late expression
  • T-cell surface protein tactile

Background

The monoclonal antibody NK92.39 reacts with CD96, also known as T cell-activated increased late expression (Tactile). CD96 promotes natural killer (NK) cell adhesion to target cells expressing the poliovirus receptor (PVR or CD155). Furthermore CD96 stimulates cytotoxicity of activated NK cells, and mediates acquisition of PVR from target cells. This means NK cells have due to the receptor CD96 a dual receptor system that recognizes nectins and nectin-like molecules on target cells and mediates NK cells adhesion and triggering of effector functions. As PVR is highly expressed in certain tumors, this receptor system may be critical for NK cell recognition of tumors. The monoclonal antibody NK92.39 blocks binding of soluble poliovirus receptor (PVR) to NK92 cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol CD96
Entrez