CD46 Antibody (FOR46) - Humanized - Low Endotoxin, Azide and BSA Free

Human CD46, His Tag Protein at 2 ug/mL can bind CD46 Antibody (FOR46) - Humanized ，EC50=0.005748ug/mL.

• Reactivity: Hu
• Applications: ELISA, Flow, Func
• Clone: FOR46
• Clonality: Monoclonal
• Host: Human
• Conjugate: Unconjugated
• Format: Low Endotoxin, Azide and BSA Free
• Concentration: LYOPH

CD46 Antibody (FOR46) - Humanized - Low Endotoxin, Azide and BSA Free Summary

• Description: The heavy chain type is huIgG1, and the light chain type is hulambda. It has a predicted MW of 145.5 kDa.
  
  This product is shipped at ambient temperature. Upon receipt, store immediately at -20C or lower for 12 months in a lyophilized state. - 80C for 3 months after reconstitution. Avoid repeated freeze-thaw cycles.
  
  Patent #: US20230383005
• Additional Information: Recombinant Monoclonal Antibody
• Immunogen: CD46
• Source: CHO
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Human
• Gene: CD46
• Purity: Protein A purified
• Endotoxin Note: < 0.001EU/ug,determined by LAL method.

Applications/Dilutions

• Dilutions:
  • ELISA
  • Flow Cytometry
  • Functional

Packaging, Storage & Formulations

• Storage: Store at -20C in powder form. Store at -80C once reconstituted.
• Buffer: Lyophilized from 25mM histidine, 8% sucrose, 0.01% Tween80 (pH6.2)
• Preservative: No Preservative
• Concentration: LYOPH
• Purity: Protein A purified
• Reconstitution Instructions: Reconstitute with sterile, distilled water to a final concentration of 1 mg/ml. Gently shake to solubilize completely. Do not vortex.

Alternate Names for CD46 Antibody (FOR46) - Humanized - Low Endotoxin, Azide and BSA Free

• AHUS2
• CD46 antigen
• CD46 molecule, complement regulatory protein
• CD46
• MCP
• membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen)
• MIC10
• TLXcomplement regulatory protein
• trophoblast leucocyte common antigen
• Trophoblast leukocyte common antigen
• trophoblast-lymphocyte cross-reactive antigen

Background

CD46 is one of the membrane complement regulatory proteins. CD46 possesses C3b-binding and factor I cofactor activities which play important roles in regulation of complement activation pathway. CD46 is widely distributed on blood cells, endothelial cells, epithelial cells and tumor cell lines. CD46 exists as many isoforms in a variety of tissues. The antigen has a broad distribution and is present on leukocytes, platelets, endothelial cells, epithelial cells and fibroblasts. It is strongly expressed on salivary gland ducts and kidney ducts, moderately on lymphocytes and endothelium, and weakly on interstitial tissues and muscle cells, but not on erythrocytes. It is expressed on thymocytes, B cells, monocytes, granulocytes, NK cells, platelets, epithelial and endothelial cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CD46
• Uniprot:
  • P15529(Human)