The antibody MEM-43 reacts with well defined epitope (W40, R-53) on CD59 (Protectin), an 18-20 kDa glycosylphosphatidylinositol (GPI)-anchored glycoprotein expressed on all hematopoietic cells; it is widely present on cells in all tissues. HLDA IV; WS Code NL 705 HLDA V; WS Code AS S013 HLDA V; WS Code BP BP345 HLDA V; WS Code T T-103
Protein A purified
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Purity is > 95% (by SDS-PAGE). Use in blocking / neutralizing reported in scientific literature (PMID 24909955)
20 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16
CD59 antigen, complement regulatory protein
CD59 molecule, complement regulatory protein
EJ30, EL32 and G344)
human leukocyte antigen MIC11
lymphocytic antigen CD59/MEM43
membrane attack complex (MAC) inhibition factor
Membrane attack complex inhibition factor
Membrane inhibitor of reactive lysis
surface anitgen recognized by monoclonal 16.3A5
T cell-activating protein
CD59 (Protectin) is a small (18-20 kDa) GPI-anchored ubiquitously expressed inhibitor of the membrane attack complex (MAC). It is thus the key regulator that preserves the autologous cells from terminal effector mechanism of the complement cascade. CD59 associates with C5b-8 complex and thereby counteracts appropriate formation of cytolytic pore within the plasma membrane. CD59 is also an low-affinity ligand of human CD2 and causes T cell costimulation.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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