CD38 Antibody (AT1) - Azide and BSA Free


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Product Details

Reactivity HuSpecies Glossary
Applications Flow, CyTOF-ready, ICC/IF
Azide and BSA Free
1.0 mg/ml

Order Details

CD38 Antibody (AT1) - Azide and BSA Free Summary

This CD38 antibody (AT1) was developed against human T cell line CCRF-CEM.
Cell surface, cytoplasm and nucleus
IgG1 Kappa
Protein A or G purified
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Test in a species/application not listed above to receive a full credit towards a future purchase.


  • Flow Cytometry 0.5 - 1 ug/million cells in 0.1 mL
  • CyTOF-ready
  • Immunofluorescence
Read Publication using NBP2-47908.

Reactivity Notes

Use in Monkey reported in scientific literature (PMID: 32478124).

Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
10 mM PBS
No Preservative
1.0 mg/ml
Protein A or G purified

Alternate Names for CD38 Antibody (AT1) - Azide and BSA Free

  • 2'-phospho-ADP-ribosyl cyclase
  • 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase (EC:
  • 2'-phospho-cyclic-ADP-ribose transferase
  • ADPRC 1
  • ADPRC1
  • ADP-ribosyl cyclase 1
  • ADP-ribosyl Cyclase
  • ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
  • ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
  • cADPr hydrolase 1
  • CD_antigen: CD38
  • CD38 antigen (p45)
  • CD38 antigen
  • CD38 molecule
  • CD38
  • cluster of differentiation 38
  • Cyclic ADP-ribose hydrolase 1
  • Cyclic ADP-ribose Hydrolase
  • EC
  • EC
  • EC:
  • NAD(+) nucleosidase
  • T10


CD38 (cluster of differentiation 38), previously known as T10, is a 46 kDa type II transmembrane glycoprotein (1). CD38 is expressed in both lymphoid and non-lymphoid tissue including in thymocytes, T and B lymphocytes, myeloid cells, natural killer cells, plasma cells, erythrocytes, and additionally in cells of the brain, pancreas, muscle, and bone (1,2). Structurally, CD38 is an "L"-shape which is formed by two separate domains connected by a three peptide-chain hinge region (2). The N-terminal domain is composed of five alpha-helices and two beta strands, while the C-terminal domain contains a four-stranded parallel beta-sheet and two long and two short alpha-helices (2). The CD38 molecule is located on chromosome 4 and is 300 amino acids (aa) in length with a theoretical molecular weight of 34 kDa that functions as both a receptor and an enzyme (1-6). As a receptor, CD38 interacts with its ligand CD31, which is largely expressed in endothelial cells (2-6). As an ectoenzyme, CD38 has a role in calcium signaling and is responsible for the conversion of nicotinamide adenine dinucleotide (NAD) into adenosine diphosphate-ribose (ADPR) or cyclic ADPR and the conversion of phosphorylated NAD (NADP) into nicotinic acid adenine dinucleotide phosphate (NAADP) (2-6).

As described above, CD38 is highly expressed in plasma cells and, as a result, is a target for treating multiple myeloma (MM), the cancer of white blood cells (4,6). The anti-CD38 monoclonal antibody daratumumab is one specific treatment for MM (4,6). Daratumumab has been shown to target MM cells through antibody-dependent cellular cytotoxicity and antibody dependent cellular phagocytosis (4). Additionally, CD38 has a potential role in neurodegenerative disorders and neuroinflammation as elucidated CD38's high expression in neurons, astrocytes, and microglia along with its enzymatic role in NAD degradation (3). Reduced NAD levels is a consequence of aging and occurs during neurodegeneration (3). Furthermore, murine studies have found that CD38 deletion inhibits neuroinflammation and neurodegeneration and therefore might be a potential therapeutic target (3). Similarly, CD38 inhibitors, like quercetin and luteolin, are used to treat age-related diseases and metabolic disorders (7).


1. Malavasi, F., Funaro, A., Alessio, M., DeMonte, L. B., Ausiello, C. M., Dianzani, U., Lanza, F., Magrini, E., Momo, M., & Roggero, S. (1992). CD38: a multi-lineage cell activation molecule with a split personality. International journal of clinical & laboratory research.

2. Malavasi, F., Deaglio, S., Funaro, A., Ferrero, E., Horenstein, A. L., Ortolan, E., Vaisitti, T., & Aydin, S. (2008). Evolution and function of the ADP ribosyl cyclase/CD38 gene family in physiology and pathology. Physiological reviews.

3. Guerreiro, S., Privat, A. L., Bressac, L., & Toulorge, D. (2020). CD38 in Neurodegeneration and Neuroinflammation. Cells.

4. van de Donk, N., Richardson, P. G., & Malavasi, F. (2018). CD38 antibodies in multiple myeloma: back to the future. Blood.

5. Lund, F. E., Cockayne, D. A., Randall, T. D., Solvason, N., Schuber, F., & Howard, M. C. (1998). CD38: a new paradigm in lymphocyte activation and signal transduction. Immunological reviews.

6. Glaria, E., & Valledor, A. F. (2020). Roles of CD38 in the Immune Response to Infection. Cells.

7. Rajman, L., Chwalek, K., & Sinclair, D. A. (2018). Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence. Cell metabolism.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for CD38 Antibody (NBP2-47908)(1)

We have publications tested in 1 confirmed species: Monkey.

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FAQs for CD38 Antibody (NBP2-47908). (Showing 1 - 1 of 1 FAQ).

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Secondary Antibodies


Isotype Controls

Other Available Formats

Alexa Fluor 350 NBP2-47908AF350
Alexa Fluor 405 NBP2-47908AF405
Alexa Fluor 488 NBP2-47908AF488
Alexa Fluor 532 NBP2-47908AF532
Alexa Fluor 594 NBP2-47908AF594
Alexa Fluor 647 NBP2-47908AF647
Alexa Fluor 700 NBP2-47908AF700
Alexa Fluor 750 NBP2-47908AF750
Allophycocyanin NBP2-47908APC
Allophycocyanin/Cy7 NBP2-47908APCCY7
Biotin NBP2-47908B
Biotin NBP2-47908B
DyLight 350 NBP2-47908UV
DyLight 405 NBP2-47908V
DyLight 488 NBP2-47908G
DyLight 550 NBP2-47908R
DyLight 594 NBP2-47908DL594
DyLight 650 NBP2-47908C
DyLight 680 NBP2-47908FR
DyLight 755 NBP2-47908IR
FITC NBP2-47908F
Janelia Fluor 549 NBP2-47908JF549
Janelia Fluor 646 NBP2-47908JF646
PE NBP2-47908PE
PE/Atto594 NBP2-47908PEATT594
PE/Cy5.5 NBP2-47908PECY55
PE/Cy7 NBP2-47908PECY7
PerCP NBP2-47908PCP

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Gene Symbol CD38