Flow Cytometry: CD3 Antibody (OKT3) - Azide Free [NBP2-24867] - Analysis of CD3+ hPMBCs using the APC conjugate of this antibody. A cell surface stain was performed on CD3+ hPBMCs with V alpha 24 J alpha 18 TCR antibody ...read more
Flow Cytometry: CD3 Antibody (OKT3) - Azide Free [NBP2-24867] - Surface staining of human PBMC with CD3 antibody (red) and isotype control (green) at 0.2 ug/10^6 cells.
Flow Cytometry: CD3 Antibody (OKT3) - Azide Free [NBP2-24867] - Surface staining of human PBMC with CD3 antibody (red) grown in serum-free media and isotype control (green) at 0.25 ug/10^6 cells.
Flow (Cell Surface): CD3 Antibody (OKT3) - Azide Free [NBP2-24867] - Analysis using the Alexa Fluor (R) 488 conjugate of NBP2-24867. Detection of CD3 expression in hPBMc's gated to lymphocyte population at 1 x 10^6 ...read more
Flow Cytometry: CD3 Antibody (OKT3) - Azide Free [NBP2-24867] - Analysis using the Alexa Fluor (R) 700 conjugate of NBP2-24867. Staining of human PBMC. Image from verified customer review.
Flow (Cell Surface): CD3 Antibody (OKT3) - Azide Free [NBP2-24867] - Analysis using the PE conjugate of NBP2-24867. Detection of CD3 expression in hPBMC's gated to lymphocyte population at 1 x 10^6 cells/ml. Cells were ...read more
Flow Cytometry: CD3 Antibody (OKT3) - Azide Free [NBP2-24867] - Analysis using Alexa Fluor (R) 488 conjugate of NBP2-24867. A cell surface stain was performed on hPBMCs with CD8 Alpha antibody (RPA-T8) NBP2-25195 (top ...read more
Mouse reactivity reported in scientific literature (PMID: 25485679)
Packaging, Storage & Formulations
Store at -20C. Avoid freeze-thaw cycles.
Filter sterilized PBS.
Protein G purified
Alternate Names for CD3 Antibody (OKT3) - Low Endotoxin and Azide Free
CD3 antigen, delta subunit
CD3d antigen, delta polypeptide (TiT3 complex)
CD3d molecule, delta (CD3-TCR complex)
CD3e antigen, epsilon polypeptide (TiT3 complex)
CD3e molecule, epsilon (CD3-TCR complex)
CD3g antigen, gamma polypeptide (TiT3 complex)
CD3g molecule, epsilon (CD3-TCR complex)
CD3g molecule, gamma (CD3-TCR complex)
T3DOKT3, delta chain
T-cell antigen receptor complex, epsilon subunit of T3
T-cell receptor T3 delta chain
T-cell surface antigen T3/Leu-4 epsilon chain
T-cell surface glycoprotein CD3 delta chain
T-cell surface glycoprotein CD3 epsilon chain
CD3 (T3), a complex Tcell marker, is known to associate noncovalently with the a/b or g/z heterodimer of the Tcell antigen receptor (TCR) to form the most complex transmembrane (TM) receptor structures. Structurally, CD3 consists of four distinct membrane glycoprotein isoforms (CD3-g, CD3-e, CD3-s and the zeta chain) to generate activation signals. CD3 is specially engaged in antigen recognition and is known to play an important role in mediating signals that are critical for Tcell development in the thymus, proliferation, and induction of Tcell-mediated immune responses against infectious agents and also in the differentiation of Tcells into effector and memory populations. It usually expresses in the cytoplasm of prothymocytes and on the surface of about 95% of thymocytes, but cytoplasmic CD3 is lost as the cells differentiate into medullary thymocytes. Apart from its role as an important marker in the classification of malignant lymphomas and lymphoid leukaemia, CD3 can also be useful for the identification of Tcells in celiac disease, lymphocytic colitis and colorectal carcinomas associated with loss of a mismatch repair protein. It indirectly plays an important role in immunomodulation whereas the CD3 antibody may be used in in vitro Treg assays to generate effector Tcells.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
FAQs for CD3 Antibody (NBP2-24867). (Showing 1 - 2 of 2 FAQs).
What the theoretical molecular weight for CD3 antibodies?
The TMW of CD3 antibodies is approximately 20 - 25 kDa.
Has this antibody been tested for the presence of any virus?
Unfortunately all of Novus' antibodies, including NBP2-24867, are just for laboratory research uses, not for any clinical diagnostics or therapeutic treatment. Therefore this antibody has not been tested for the presence of any virus, as required by the rules of GMP for all clinical products.
Transferrin and the blood brain barrier Transferrin, an iron binding protein that facilitates iron uptake in cells, is an integral part of a mechanism that may introduce antibody therapies to the central nervous system. Currently, the brain’s ability to take in antibody therapies i... Read full blog post.
MHC Class I and the Herpes Simplex Virus MHC molecules (also known as major histocompatibility complex molecules) assist in the presentation of antigens to T cells in order to eradicate foreign pathogens. These molecules are highly polymorphic, meaning that they exist in multiple varian... Read full blog post.
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