CD21 Antibody (BB6-11C9.6) [Alexa Fluor® 647]

CD21 Antibody (BB6-11C9.6) [Alexa Fluor® 647] [NBP1-28245AF647] - Vial of Alexa Fluor 647 conjugated antibody. Alexa Fluor 647 is optimally excited at 653 nm by the Red laser (633 or 640 nm) and has an emission maximum of 669 nm.

• Reactivity: Mu, Po
• Applications: Flow
• Clone: BB6-11C9.6
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 647

CD21 Antibody (BB6-11C9.6) [Alexa Fluor® 647] Summary

• Immunogen: Porcine CD21, Mr 160 kDa
• Marker: Histiocytic Marker
• Specificity: Porcine CD21, Mr 160 kDa
• Isotype: IgG1 Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: CR2
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry

Reactivity Notes

Mouse reactivity reported in scientific literature (PMID: 26284585). Use in Mouse reported in scientific literature (PMID:26284585).

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified

Notes

Alexa Fluor (R) products are provided under an intellectual property license from Life Technologies Corporation. The purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: (i) in manufacturing; (ii) to provide a service, information, or data in return for payment; (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@lifetech.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for CD21 Antibody (BB6-11C9.6) [Alexa Fluor® 647]

• C3DR
• C3DRSLEB9
• CD21 antigen
• CD21
• Complement C3d receptor
• complement component (3d/Epstein Barr virus) receptor 2
• complement receptor type 2
• CR2
• EBV receptor
• Epstein-Barr virus receptor

Background

CD21 (complement receptor 2, CR2) binds C3 complement fragments, especially its breakdown fragments, which remain covalently attached to complement activating surfaces or antigen. CD21 has important roles in uptake and retention of immunocomplexes, survival of memory B cells and in development and maintenance of the humoral response to T-dependent antigens. CD21 also serves as a key receptor for Epstein-Barr virus binding and is involved in targeting prions to folicular dendritic cells and expediting neuroinvasion following peripheral exposure to prions. A soluble form of the CD21 (sCD21) is shed from the lymphocyte surface and retains its ability to bind respective ligands.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for CD21 Antibody (NBP1-28245AF647)(1)

Publication using NBP1-28245AF647

• John-Schuster G, Gunter S, Hager K et al. Inflammaging increases susceptibility to cigarette smoke-induced COPD. Oncotarget. 2016-05-24 [PMID: 26284585] (Mouse)
  
  Details:
  This citation used the Alexa Fluor 647 version of this antibody.

Bioinformatics

• Gene Symbol: CR2