Purified receptor for the C3d fragment of the third complement component CR2, from human tonsil.
This CD21 Antibody (1F8) reacts with CD21 antigen of MW 145 kDa, present on the surface of mature B cells. The antigen is present at high density on follicular dendritic cells. CD21 is involved in transmitting growth-promoting signals to the interior of the B cell.
Tissue culture supernatant
Test in a species/application not listed above to receive a full credit towards a future purchase.
CD21 also known as complement receptor 2 (CR2), C3d receptor or EBV receptor is a 140 kDa protein. CD21 is a glycosylated type I transmembrane protein consisting of an extracellular face of a series of 15 or 16 CCP domains. CD21 is the receptor for complement components C3d and iC3b as well as the Epstein-Barr virus (EBV) glycoprotein gp350/220. The soluble CD21 (sCD21) was shown to efficiently trigger CD23 signaling pathways in human monocytes. By inducing release of proinflammatory cytokines and upregulating expression of molecules involved in antigen presentation, sCD21 modulates critical monocyte functions that may be relevant to allergic and inflammatory disorders.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
1:10 & 1:25 dilutions were tested on human tonsil and cynomolgus monkey spleen and tonsil tissue. An anti-mouse polymer was used for detection. The human tonsil stained nicely, but there was no staining in the monkey tissues.
Product General Protocols
Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.
CD19: An Undoubted Biomarker for B Cells CD19 is a cell surface protein member of the large immunoglobulin superfamily that complexes with CD21, CD81, and CD225 in the membrane of mature B-cells. A major function of CD19 is to assemble with the antigen receptor of B-lymphocytes to decrease t... Read full blog post.
The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.