CD21 Antibody (1F8)

Images

 
Immunohistochemistry-Paraffin: CD21 Antibody (1F8) [NBP1-22527] - Human tonsil tissue section stained with CD21 antibody. IHC-P image submitted by a verified customer review.
Immunohistochemistry-Paraffin: CD21 Antibody (1F8) [NBP1-22527] - Formalin fixed paraffin embedded human tonsil stained with CD21 antibody (NBP1-22527).

Product Details

Summary
Reactivity Hu, PmSpecies Glossary
Applications IHC, IHC-P
Clone
1F8
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

CD21 Antibody (1F8) Summary

Immunogen
Purified receptor for the C3d fragment of the third complement component CR2, from human tonsil.
Localization
Cell membrane
Marker
Histiocytic Marker
Specificity
This CD21 Antibody (1F8) reacts with CD21 antigen of MW 145 kDa, present on the surface of mature B cells. The antigen is present at high density on follicular dendritic cells. CD21 is involved in transmitting growth-promoting signals to the interior of the B cell.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
CR2
Purity
Tissue culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:10 - 1:500
  • Immunohistochemistry-Paraffin 1:10 - 1:500
Reviewed Applications
Read 2 Reviews rated 4.5
using
NBP1-22527 in the following applications:

Reactivity Notes

Monkey reactivity reported from a verified customer review.

Packaging, Storage & Formulations

Storage
Store at 4C.
Buffer
Tissue culture supernatant
Preservative
0.09% Sodium Azide
Purity
Tissue culture supernatant

Alternate Names for CD21 Antibody (1F8)

  • C3DR
  • C3DRSLEB9
  • CD21 antigen
  • CD21
  • Complement C3d receptor
  • complement component (3d/Epstein Barr virus) receptor 2
  • complement receptor type 2
  • CR2
  • EBV receptor
  • Epstein-Barr virus receptor

Background

CD21 also known as complement receptor 2 (CR2), C3d receptor or EBV receptor is a 140 kDa protein. CD21 is a glycosylated type I transmembrane protein consisting of an extracellular face of a series of 15 or 16 CCP domains. CD21 is the receptor for complement components C3d and iC3b as well as the Epstein-Barr virus (EBV) glycoprotein gp350/220. The soluble CD21 (sCD21) was shown to efficiently trigger CD23 signaling pathways in human monocytes. By inducing release of proinflammatory cytokines and upregulating expression of molecules involved in antigen presentation, sCD21 modulates critical monocyte functions that may be relevant to allergic and inflammatory disorders.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for CD21 Antibody (NBP1-22527) (0)

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Reviews for CD21 Antibody (NBP1-22527) (2) 4.52

Average Rating: 4.5
(Based on 2 reviews)
We have 2 reviews tested in 2 species: Human, Cynomolgus monkey.

Reviews using NBP1-22527:
Filter by Applications
IHC-P
(2)
All Applications
Filter by Species
Human
(1)
Cynomolgus monkey
(1)
All Species
Images Ratings Applications Species Date Details
Immunohistochemistry-Paraffin CD21 NBP1-22527
Enlarge
5
reviewed by:
Anonymous
IHC-P Human 01/27/2021
View

Summary

ApplicationImmunohistochemistry-Paraffin
Sample Testedhuman tonsil
SpeciesHuman
LotP827
Immunohistochemistry-Paraffin CD21 NBP1-22527
Enlarge
4
reviewed by:
Anonymous
IHC-P Cynomolgus monkey 01/27/2021
View

Summary

ApplicationImmunohistochemistry-Paraffin
Sample Testedcynomolgus monkey spleen
SpeciesCynomolgus monkey
LotP827

Comments

Comments1:10 & 1:25 dilutions were tested on human tonsil and cynomolgus monkey spleen and tonsil tissue. An anti-mouse polymer was used for detection. The human tonsil stained nicely, but there was no staining in the monkey tissues.

Product General Protocols

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FAQs for CD21 Antibody (NBP1-22527) (0)

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Secondary Antibodies

 

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How to identify B cell subsets using flow cytometry
By Victoria OsinskiUsing flow cytometry to identify B cell subsetsIdentifying cellular subsets by flow cytometry requires careful and thorough planning in order to ensure the correct subset of cells are identified a...  Read full blog post.

CD19: An Undoubted Biomarker for B Cells
CD19 is a cell surface protein member of the large immunoglobulin superfamily that complexes with CD21, CD81, and CD225 in the membrane of mature B-cells. A major function of CD19 is to assemble with the antigen receptor of B-lymphocytes to decrease t...  Read full blog post.

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Recent Reviews

4.5
5
1
4
1
3
0
2
0
1
0

Anonymous
01/27/2021
Application: IHC-P
Species: Human

Anonymous
01/27/2021
Application: IHC-P
Species: Cynomolgus monkey

Bioinformatics

Gene Symbol CR2
Entrez
Uniprot