CD11c Antibody (ITGAX/1243) [Alexa Fluor® 488] Summary
Recombinant fragment (191 Amino acid residues between aa 600-850) of human ITGAX protein
Dendritic Cell Marker
Recognizes a protein of 145kDa, identified as CD11c. CD11c (ITGAX), a member of the leukointegrin family, shares the same beta subunit with other members of the leukocyte adhesion molecule family, which includes CD11a (LFA-1), CD11b (MAC-1) and CD11d (ITGAD), but has a unique alpha chain. CD11c has been shown to play a role in phagocytosis, cell migration, and cytokine production by monocytes/macrophages as well as induction of T-cell proliferation by Langerhans cells. CD11c is expressed prominently on the plasma membranes of monocytes, tissue macrophages, NK cells, and most dendritic cells (DCs). A lower level of expression is also observed on neutrophils as a result of its high level of expression on most DCs. An antibody to CD11c may aid in identification of lesions with histiocytic origin. It may also been used as a marker for hairy cell leukemia in paraffin-embedded tissues
Protein A or G purified
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- Flow Cytometry
Optimal dilution of this antibody should be experimentally determined.
Packaging, Storage & Formulations
Store at 4C in the dark.
50mM Sodium Borate
0.05% Sodium Azide
Protein A or G purified
Alexa Fluor (R) products are provided under an intellectual property license from Life Technologies Corporation. The purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: (i) in manufacturing; (ii) to provide a service, information, or data in return for payment; (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad, CA 92008 USA or firstname.lastname@example.org. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.
Alternate Names for CD11c Antibody (ITGAX/1243) [Alexa Fluor® 488]
- 95 alpha chain
- 95, alpha subunit
- CD11 antigen-like family member C
- CD11c antigen
- CD11Cleu M5, alpha subunit
- Integrin alpha X
- integrin alpha-X
- integrin, alpha X (antigen CD11C (p150), alpha polypeptide)
- integrin, alpha X (complement component 3 receptor 4 subunit)
- Leu M5
- Leukocyte adhesion glycoprotein p150
- Leukocyte adhesion receptor p150
- leukocyte surface antigen p150
- myeloid membrane antigen, alpha subunit
- p150 95 integrin alpha chain
- p150,95 alpha
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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