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CD11a/CD18 Antibody (hu1124 (Efalizumab)) - Chimeric - Azide and BSA Free

Images

 
Immunohistochemistry: CD11a/CD18 Antibody (hu1124 (Efalizumab)) - Chimeric [NBP2-52686] - Anti-CD11a staining of formaldehyde fixed paraffin embedded rat spleen tissue, at 40x magnification. The human IgG1-chimeric ...read more
Flow Cytometry: CD11a/CD18 Antibody (hu1124 (Efalizumab)) - Chimeric [NBP2-52686] - Flow-cytometry using the anti-CD11a research biosimilar antibody Efalizumab. Human lymphocytes were stained with an isotype control ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, IHC, B/N, CyTOF-ready
Clone
hu1124 (Efalizumab)
Clonality
Monoclonal
Host
Rabbit
Conjugate
Unconjugated
Format
Azide and BSA Free
Concentration
1 mg/ml

Order Details

CD11a/CD18 Antibody (hu1124 (Efalizumab)) - Chimeric - Azide and BSA Free Summary

Additional Information
Recombinant Monoclonal Antibody.
Immunogen
Efalizumab binds to CD11a, a subunit of leukocyte function antigen-1 (LFA-1), which is expressed on all leukocytes.
Specificity
Binds to human LFA-1.
Isotype
IgG Kappa
Clonality
Monoclonal
Host
Rabbit
Gene
ITGAL
Purity
Protein A purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Block/Neutralize
  • CyTOF-ready
  • Flow Cytometry 1:10 - 1:1000
  • Immunohistochemistry
Application Notes
This antibody is Cytof ready. This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques. Efalizumab binds to the LFA-1 alpha I domain blocking the ICAM-1 binding site via steric hindrance.
Publications
Read Publication using
NBP2-52686 in the following applications:

  • B/N
    1 publication

Packaging, Storage & Formulations

Storage
Store at 4C for up to 3 months. For longer storage, aliquot and store at -20C.
Buffer
PBS
Preservative
0.02% Proclin 300
Concentration
1 mg/ml
Purity
Protein A purified

Alternate Names for CD11a/CD18 Antibody (hu1124 (Efalizumab)) - Chimeric - Azide and BSA Free

  • biosimilar antibody
  • biosimilars
  • CD11 antigen-like family member A
  • CD11a antigen
  • CD11Aantigen CD11A (p180), lymphocyte function-associated antigen 1, alphapolypeptide
  • integrin alpha-L
  • integrin gene promoter
  • integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen1; alpha polypeptide)
  • Leukocyte adhesion glycoprotein LFA-1 alpha chain
  • Leukocyte function-associated molecule 1 alpha chain
  • LFA-1 alpha
  • LFA-1
  • LFA1A
  • LFA-1A
  • lymphocyte function-associated antigen 1

Background

The CD11/18 complex of glycoproteins are dimers comprised of a common beta chain and individual alpha chains (CD11a/18 or CD11b/18 and CD11c/18). CD11a/18 is a receptor for C3bi, a complement component, CD11b/18 is Lymphocyte Function Activator, and CDD11c/18 is a lectin-like glycoprotein thought to be important for mediation of cells to other surfaces.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for CD11a/CD18 Antibody (NBP2-52686)(1)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: B/N.


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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol ITGAL